FIGURE

FIGURE 4

ID

ZDB-FIG-220316-35

Publication

Messerschmidt et al., 2022 - In vivo Evaluation of Non-viral NICD Plasmid-Loaded PLGA Nanoparticles in Developing Zebrafish to Improve Cardiac Functions

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 4

RT-PCR analysis after injecting intravenous NICD loaded nanoparticles. (A) Notch signaling components were all upregulated after injection of NICD loaded nanoparticles until 24 h post injection. However, Notch ligand (dll4) and receptor (notch1b) were returned to control group (saline injection) level while downstream components (nrg1 and hey1) remain high with NICD expression level. (B) Isolated zebrafish heart after injection showed higher expression levels of Notch components to increase cardiac function. Interestingly, endocardial nrg1-myocardial erbb2 signaling components consistently increased up to 48 h post injection. * indicates a significant difference (p < 0.01). n = 5.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Physiol.