ZFIN Image: Messerschmidt et al., 2022, FIGURE 4

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Figure Caption

FIGURE 4

RT-PCR analysis after injecting intravenous NICD loaded nanoparticles. (A) Notch signaling components were all upregulated after injection of NICD loaded nanoparticles until 24 h post injection. However, Notch ligand (dll4) and receptor (notch1b) were returned to control group (saline injection) level while downstream components (nrg1 and hey1) remain high with NICD expression level. (B) Isolated zebrafish heart after injection showed higher expression levels of Notch components to increase cardiac function. Interestingly, endocardial nrg1-myocardial erbb2 signaling components consistently increased up to 48 h post injection. * indicates a significant difference (p < 0.01). n = 5.

Acknowledgments

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