FIGURE

Figure 4—figure supplement 1.

ID

ZDB-FIG-220314-77

Publication

Qi et al., 2022 - Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

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Figure 4—figure supplement 1.

<italic toggle='yes'>aplnrb</italic> mutants exhibit reduced endocardial protrusion formation and reduced trabeculation, and <italic toggle='yes'>aplnra</italic> mutant exhibit a mild reduction in trabeculation.

(A–F) Confocal projection images of the heart of Tg(kdrl:HsHRAS-mCherry) (A–B) and Tg(myl7:HsHRAS-EGFP); Tg(kdrl:HsHRAS-mCherry) (C–F) zebrafish at 48 (A–B) and 72 (C–F) hours post-fertilization (hpf). (A–B) aplnrb^-/- embryos exhibit fewer endocardial protrusions (arrows) compared with aplnrb^+/+ siblings (A) at 48 hpf. (C–D) aplnrb^-/- larvae (D) exhibit reduced trabeculation (arrowheads) and thicker cardiac jelly (CJ) (asterisk) compared with aplnrb^+/+ siblings (C) at 72 hpf. (E–F) aplnra^-/- larvae (F) exhibit a mild reduction in trabeculation compared with aplnra^+/+ siblings (E) at 72 hpf. V, ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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