FIGURE

Fig. 7

ID

ZDB-FIG-220207-7

Publication

Yu et al., 2021 - Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence

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Fig. 7

A proposed model accounting for the observed mutually exclusive pattern of BAP1 and SF3B1 mutations in UM. The transcriptional suppression of DNA‐repair genes derived from co‐occurrence of BAP1 deficiency and SF3B1 hotspot mutation (R625H) impairs cells’ capacity to buffer endogenous DNA damage and consequently leads to DNA damage and senescence. These data provide a functional explanation for the observed mutual exclusivity of BAP1 and SF3B1 mutations in UM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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