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Fig. 7

ID: ZDB-IMAGE-220207-7
Source: Figures for Yu et al., 2021

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Fig. 7

A proposed model accounting for the observed mutually exclusive pattern of BAP1 and SF3B1 mutations in UM. The transcriptional suppression of DNA‐repair genes derived from co‐occurrence of BAP1 deficiency and SF3B1 hotspot mutation (R625H) impairs cells’ capacity to buffer endogenous DNA damage and consequently leads to DNA damage and senescence. These data provide a functional explanation for the observed mutual exclusivity of BAP1 and SF3B1 mutations in UM.

Acknowledgments

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