FIGURE

Figure 2

ID

ZDB-FIG-210711-7

Publication

Wang et al., 2021 - BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration

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Figure 2

BMP signaling acts downstream of Notch signaling during ventricle regeneration. (A-C) Whole-mount in situ hybridizations showed upregulated bmp10 expression in ablated hearts at 2 dpt could be blocked by Notch signaling inhibitor DAPT but not BMP signaling inhibitor DM. (D-F) Confocal stack projections of Tg(vmhc:mCherry-NTR; Bre:dGFP) hearts showed BMP signaling activation at 2 dpt could be blocked by both DAPT and DM. (G-I) Whole-mount in situ hybridizations showed upregulated notch1b expression in ablated hearts at 1 dpt could be blocked by DAPT but not DM. (J-L) Confocal stack projections of Tg(vmhc:mCherry-NTR; tp1:dGFP) hearts showed Notch signaling activation at 1 dpt could be attenuated by DAPT but not DM. Asterisk, Notch signal at the atrioventricular canal. Scale bars, (A-C, G-I) 25 µm, (D-F, J-L) 50 µm. dpt, days post MTZ-treatment; A, atrium; V, ventricle; DM, dorsomorphin. Dashed lines outline the hearts.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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