FIGURE

FIGURE 4

ID

ZDB-FIG-210319-64

Publication

Vishnolia et al., 2021 - sGC Activity and Regulation of Blood Flow in a Zebrafish Model System

Other Figures

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FIGURE 4

(A) Graph presents cGMP levels (p mol per larvae) measured from AB-wild-type larvae at 4 dpf treated with H₂O, 1, 5, and 10 μM BAY41-2272 concentration. (B) cGMP levels measured and compared from gucy1a1^+/– treated with H₂O, 1, 5, and 10 μM BAY41-2272 concentration. (C) cGMP levels measured and compared between AB-wild types, morpholino injected controls, gucy1a1-MO, gucy1b1-MO, and gucy1a1+gucy1b1-MO. Data are presented as mean ± standard deviation from n = 30 larvae per group, significance was set at p < 0.05, and stars denote the significant differences.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB AB + MO1-gucy1b1 AB + MO2-gucy1a1 gucy1a1^zf3477/+ (AB) AB + MO1-gucy1b1 + MO2-gucy1a1
Condition:	chemical treatment by environment: BAY 41-2272
Knockdown Reagents:	MO1-gucy1b1 MO2-gucy1a1
Observed In:	whole organism 3',5'-cyclic GMP
Stage:	Day 4

Phenotype Detail

Acknowledgments

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