FIGURE

FIGURE 5

ID

ZDB-FIG-210125-11

Publication

Li et al., 2020 - Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury in the zebrafish lateral line via multiple pathways

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FIGURE 5

Protective effect of naringin against Mitochondrial oxidative stress and cilia damage. Zebrafish were treated with different concentrations of ototoxic drugs with or without Nar. Control animals were exposed to vehicle alone (DMSO). Still images of live brn3c: GFP hair cells (green) loaded with the live fluorescent indicator mitoSOX (red). (A) The top view of hair cell clusters to show the morphology of hair cells. (B) The mitoSOX fluorescent intensity per neuromast was calculated for each treatment and represented as mean ± SEM. ***P < 0.001. Black asterisks compared to DMSO‐treated animals. Red asterisks compared versus the corresponding ototoxin‐only treatment. (C) Side view of hair cell clusters to show hair cell cilia. (D) Quantification of the number of surviving cilia per neuromast after the different treatments represented as mean ± SEM. ***P < 0.001. Black asterisks compared to DMSO‐treated animals. Red asterisks compared versus the corresponding ototoxin‐only treatment

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.