FIGURE

Figure 5

ID

ZDB-FIG-201214-15

Publication

Chang et al., 2020 - Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

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Figure 5

Tangeretin (TAN) remarkably ameliorated PMA induced epidermal hyperplasia intra-epidermal neutrophilic abscesses (mice, n = 5/group). (A) Ear thickness was measured every day after topical treatment of PMA and TAN for 3 days, (B) Ear weight of different mice group after sacrifice, (C) Epidermal thickness of mice ears measured through hematoxylin and eosin (H&E) staining data, (D) Serum IgE estimation from PMA treated mice, (E) Estimating the infiltrating inflammatory cells/area from H&E staining images, (F) Representative images of mice ear tissues after PMA induced inflammation measured through H&E staining. Square: the regions under the square represent massive re-epithelialization occurring after PMA treatment over a period of 3 days. Newly formed, thick epidermis as observed on PMA group. Black arrow: the marked regions on the images shows highly aggregated granulation tissue and an inflammatory cell rush comprising of scattered neutrophils, macrophages and other inflammatory cells. Scale bar (100 μM). The data are represented as mean ± S.D. of two independent experiments * p < 0.05, ** p < 0.01, *** p < 0.001 and ns (non-significant). Control vs. PMA, PMA vs. TAN 10 mg/kg and 30 mg/kg. Statistical significance analysis was carried out through a one-way analysis of variance (ANOVA) prism.

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Acknowledgments

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