ZFIN ID: ZDB-FIG-200416-20
Charlton-Perkins et al., 2019 - Genetic control of cellular morphogenesis in Müller glia. Glia   67(7):1401-1411 Full text @ Glia
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Day 5

Table S4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mi2001Tg + CRISPR1-apcdd1l + CRISPR2-apcdd1l standard conditions Day 5 Muller cell glial cell projection increased thickness, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-cadm1b + CRISPR2-cadm1b standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-cadm2b + CRISPR2-cadm2b standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-cadm4 + CRISPR2-cadm4 standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-cdhr1a + CRISPR2-cdhr1a standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell cell body spatial pattern, abnormal
Day 5 Muller cell glial cell projection mislocalised, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 outer limiting membrane irregular thickness, abnormal
Day 5 retinal inner plexiform layer decreased size, abnormal
Day 5 retinal neural layer lacks parts or has fewer parts of type inner limiting membrane, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-cux2b + CRISPR2-cux2b standard conditions Day 5 inner limiting membrane morphology, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-dcaf8 + CRISPR2-dcaf8 standard conditions Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-egr1 + CRISPR2-egr1 standard conditions Day 5 Muller cell glial cell projection position, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-f8 + CRISPR2-f8 standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell cell body mislocalised, abnormal
Day 5 Muller cell cell body position, abnormal
Day 5 Muller cell glial cell projection mislocalised, abnormal
Day 5 Muller cell glial cell projection structure, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-fat1b + CRISPR2-fat1b standard conditions Day 5 Muller cell glial cell projection increased thickness, abnormal
Day 5 Muller cell glial cell projection morphology, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
Day 5 retinal outer plexiform layer increased thickness, abnormal
mi2001Tg + CRISPR1-gjb1b + CRISPR2-gjb1b standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR1-icn2 + CRISPR2-icn2 standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR1-itga5 + CRISPR2-itga5 standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell glial cell projection increased thickness, abnormal
Day 5 Muller cell glial cell projection position, abnormal
Day 5 Muller cell glial limiting end-foot decreased amount, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
mi2001Tg + CRISPR1-itga6b + CRISPR2-itga6b standard conditions Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-itgb1a + CRISPR2-itgb1a standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell glial limiting end-foot decreased amount, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
mi2001Tg + CRISPR1-kirrel1a + CRISPR2-kirrel1a standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR1-lamb2 + CRISPR2-lamb2 standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell cell body spatial pattern, abnormal
Day 5 Muller cell glial cell projection morphology, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell glial cell projection spatial pattern, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
Day 5 retinal neural layer lacks parts or has fewer parts of type inner limiting membrane, abnormal
mi2001Tg + CRISPR1-lamb4 + CRISPR2-lamb4 standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR1-map1ab + CRISPR2-map1ab standard conditions Day 5 Muller cell glial cell projection increased thickness, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 outer limiting membrane irregular thickness, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-mmp28 + CRISPR2-mmp28 standard conditions Day 5 Muller cell glial limiting end-foot absent, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal neural layer lacks parts or has fewer parts of type inner limiting membrane, abnormal
mi2001Tg + CRISPR1-myo6b + CRISPR2-myo6b standard conditions Day 5 Muller cell glial cell projection increased thickness, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-nav1b + CRISPR2-nav1b standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell cell body mislocalised, abnormal
Day 5 Muller cell cell body position, abnormal
Day 5 Muller cell cell body spatial pattern, abnormal
Day 5 Muller cell glial cell projection decreased amount, abnormal
Day 5 Muller cell glial cell projection mislocalised, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
mi2001Tg + CRISPR1-nfat5b + CRISPR2-nfat5b standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR1-nphs1 + CRISPR2-nphs1 standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-prmt6 + CRISPR2-prmt6 standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection increased thickness, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
mi2001Tg + CRISPR1-seraf + CRISPR2-seraf standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-slitrk2 + CRISPR2-slitrk2 standard conditions Day 5 Muller cell physical object quality, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-snx19a + CRISPR2-snx19a standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR1-sptbn5 + CRISPR2-sptbn5 standard conditions Day 5 Muller cell cell body spatial pattern, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 outer limiting membrane irregular thickness, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR1-sypb + CRISPR2-sypb standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR10-cacnb2a + CRISPR1-cacnb2a standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR2-cadm1a + CRISPR3-cadm1a standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR2-pals2b + CRISPR3-pals2b standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR2-timp2b + CRISPR3-timp2b standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR3-nphp1 + CRISPR4-nphp1 standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
mi2001Tg + CRISPR3-sox10 + CRISPR4-sox10 standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer irregular thickness, abnormal
mi2001Tg + CRISPR3-wt1b + CRISPR4-wt1b standard conditions Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
mi2001Tg + CRISPR3-xirp1 + CRISPR4-xirp1 standard conditions Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell glial cell projection spatial pattern, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 retinal outer plexiform layer morphology, abnormal
mi2001Tg + CRISPR5-mmp2 + CRISPR6-mmp2 standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell glial limiting end-foot decreased amount, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
mi2001Tg + CRISPR5-pax2a + CRISPR6-pax2a standard conditions Day 5 inner limiting membrane broken, abnormal
Day 5 Muller cell cell body displaced, abnormal
Day 5 Muller cell glial cell projection overlap with Muller cell glial cell projection, abnormal
Day 5 Muller cell morphology, abnormal
Day 5 Muller cell physical object quality, abnormal
Day 5 outer limiting membrane broken, abnormal
Day 5 retinal inner plexiform layer decreased thickness, abnormal
Day 5 retinal inner plexiform layer morphology, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Glia