FIGURE

Figure 9

ID

ZDB-FIG-191230-1752

Publication

Copmans et al., 2019 - Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B

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Figure 9

Antiseizure activity analysis of TMC-120A and TMC-120B in the mouse 6-Hz (44 mA) psychomotor seizure model. Drug-resistant psychomotor seizures were induced by electrical stimulation through the cornea, 30 min after i.p. injection of vehicle (VHC, n = 20), positive control valproate (n = 12), TMC-120A (n = 4–8) or TMC-120B (n = 5–6). Mean seizure durations (±SD) are depicted. Statistical analysis: one-way ANOVA with Dunnett’s multiple comparison test (GraphPad Prism 5, San Diego, CA, USA). Significance levels: * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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