FIGURE

Fig. 2

ID

ZDB-FIG-190606-37

Publication

Pickett et al., 2018 - Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells

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Fig. 2

Acute mitochondrial activity is reduced in the absence of MET.

(A, B) Maximum projections of hair cells from WT/Het and sputnik mutant siblings incubated in JC-1 dye. Hair cells were imaged from a dorsal view, as indicated in the schematic shown in Figure 1—figure supplement 1B. (C) Mean JC-1 fluorescence plotted as a ratio of red:green. WT/Het: 0.25 ± 0.24 n = 8 fish; Mutant: 0.05 ± 0.07 n = 8 fish; mean ratio ± SD. Mann-Whitney U test was used to assess significance. Value for each fish represents the mean of 3 neuromasts. Scale bar = 5 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cdh23^tj264/tj264
Observed In:	neuromast hair cell mitochondrion neuromast hair cell regulation of mitochondrial membrane potential
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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