FIGURE

Fig. 5

ID

ZDB-FIG-180911-45

Publication

Oosterhof et al., 2018 - Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

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Fig. 5

Differential Gene Expression of csf1r-Deficient Microglia Shows Normal Microglia Differentiation

(A) Volcano plot showing expressional changes of the 300 most highly expressed microglia-specific genes in csf1ra^−/−;b^+/− mutant microglia (Oosterhof et al., 2017).

(B) Volcano plot showing the expressional changes in csf1ra^−/−;b^+/− mutant microglia of normally downregulated genes during differentiation (Matcovitch-Natan et al., 2016) and of genes normally expressed in other macrophages in the CNS (Bennett et al., 2016).

(D) Expression values of zebrafish microglia-specific genes.

(E) Expression values of downregulated microglia-specific genes.

(F) Expression values of upregulated microglia-specific genes.

(G) Representative images of microglia (5-month-old fish) in the ventral part of the optic tectum labeled with an antibody against L-plastin. Scale bar, 20 μm.

Expression Data

Antibody:	Ab2-lcp1
Fish:	AB csf1ra^j4e1/j4e1; csf1rb^re01/+
Anatomical Term:	optic tectum microglial cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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