ZFIN ID: ZDB-FIG-180522-36
Fadeev et al., 2018 - ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells. Proceedings of the National Academy of Sciences of the United States of America   115(4):E630-E638 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 1

Ectopic expression of ALKALs and overactivation of DrLtk leads to supernumerary iridophores in D. rerio. (A) Domain structure of the human and zebrafish ALK/LTK RTK family. GR, glycine rich; L, LDLa; M, MAM; PTK, kinase domain; TM, transmembrane domain. The activating F993I (DrLtk) and F1174L (HsALK) mutations within the kinase domain are indicated. (B) ltk loss-of-function shady mutants (ltkj9s1) lack iridophores, while gain-of-function moonstone (ltkmne) exhibit increased numbers of iridophores. (C) Alignment of ALKAL proteins from different species. Underlined, the FAM150 domain; red asterisks, conserved Cys. Note high conservation of the C-terminal half of the FAM150 domain.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ltkdtwc3/dtwc3 standard conditions Adult iridophore increased amount, abnormal
Adult whole organism has extra parts of type iridophore, abnormal
ltkj9s1/j9s1 standard conditions Adult iridophore decreased amount, abnormal
Adult whole organism lacks all parts of type iridophore, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proceedings of the National Academy of Sciences of the United States of America for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA