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Fig. 5

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ZDB-FIG-180424-22

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Uribe et al., 2017 - Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells

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Fig. 5

Temporal loss of RA causes total intestinal aganglionosis. (A-B) Lateral view of the foregut of a control (A) and DEAB treated larval fish (B) following double immunochemistry against Hu (red) and 5HT (green) shows that control fish successfully differentiate enteric neurons, while DEAB treated fish lack almost all neurons. A small cluster of ~3 neurons was detected in the anterior foregut of the DEAB treated larval fish (arrow in B). (C-D) Lateral view of the foregut of a control (C) and DEAB treated larval fish (D) following immunochemistry against Acetylated Tubulin shows that control fish contain differentiated enteric neurons, along with axons (arrows), while DEAB treated larval fish do not. Scale bar in A and C: 30 μM. Anterior to the left.

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Antibody Labeling

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Reprinted from Developmental Biology, 433(1), Uribe, R.A., Hong, S.S., Bronner, M.E., Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells, 17-32, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.