ZFIN ID: ZDB-FIG-171101-33
Astone et al., 2015 - A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish. PLoS One   10:e0145178 Full text @ PLoS One
Observed In:
Stage: Adult

Fig. 5

Representative histological features of the ia2 abdominal carcinomas.

(A) Abdominal tumors arise beneath the swim bladder, in close proximity with the gut, pancreas and liver. The neoplastic cells occasionally infiltrate the hepatic parenchyma (arrows) and the intestinal wall (arrowhead). (B, C) Cytologically, the tumor is composed of polygonal cells with abundant eosinophilic cytoplasm. In most cases, a sub-population of epithelioid cells with more basophil cytoplasm is also faced (arrow). (D) The abdominal carcinomas consistently express the pan-cytokeratin AE1/AE3 (brown staining). See Fig 4A for the normal abdominal region.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
unm_ia2ia2Tg/+; unm_ia2Df(Chr01:timm10,rtn4rl2a,p2rx3b,pkd2,slc27a1b)ia2a/+ standard conditions Adult trunk carcinoma increased amount, abnormal
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