ZFIN ID: ZDB-FIG-171101-30
Astone et al., 2015 - A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish. PLoS One   10:e0145178 Full text @ PLoS One
Observed In:
Stage: Prim-5

Fig. 2

Morphological alterations of ia2/ia2 mutant at 24 hpf.

(A, A’) Head side view: mutant embryos display a relevant delay in head structures development, with just sketchy eye, when visible. (B, B’) Somites side view, showing their poorly defined shape and boundaries in the mutant. Globular cells with impaired adhesion are also visible. (C, C’) Notochord dorsal view: in mutant embryos notochord bending on the coronal plane is evident. (D, D’) Notochord side view, showing how notochord cells structure is also affected in mutant embryos, with globular and disorganized vacuoles, compared to the stretched and flanked ones of the wild-type. (E, E’) Tail terminal portion, side view: the notochord is indistinguishable in the mutant and the mesenchyme seems disaggregated with many non-adherent globular cells. Scale bar 50 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
unm_ia2ia2Tg/ia2Tg; unm_ia2Df(Chr01:timm10,rtn4rl2a,p2rx3b,pkd2,slc27a1b)ia2a/ia2a standard conditions Prim-5 caudal fin mesenchyme structure, abnormal
Prim-5 eye morphology, abnormal
Prim-5 head embryo development delayed, abnormal
Prim-5 notochord bent, abnormal
Prim-5 notochord cell spherical, abnormal
Prim-5 notochord vacuole disorganized, abnormal
Prim-5 somite cell decreased adhesivity, abnormal
Prim-5 somite cell spherical, abnormal
Prim-5 somite structure, abnormal
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One