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ZIRC
ZFIN ID: ZDB-FIG-170628-29
Schmid et al., 2013 - Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proc. Natl. Acad. Sci. USA   110(13):4986-91 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Prim-5 to Days 7-13

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
s896Tg ; tardbpmde198/mde198 ; tardbplmde159/mde159(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
s896Tg ; tardbpmde897/mde897 ; tardbplmde159/mde159(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
s896Tg ; tardbpmde909/mde909 ; tardbplmde114/mde114(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
s896Tg ; tardbpmde909/mde909 ; tardbplmde222/mde222(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
s896Tg ; tardbpmde948/mde948 ; tardbplmde114/mde114(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
s896Tg ; tardbpmde948/mde948 ; tardbplmde159/mde159(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde150/mde150(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbpmde150/mde150 ; tardbplmde114/mde114 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde150/mde150 ; tardbplmde159/mde159(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde150/mde150 ; tardbplmde222/mde222(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde198/mde198(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbpmde198/mde198 ; tardbplmde159/mde159(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde198/mde198 ; tardbplmde222/mde222 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde201/mde201(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbpmde201/mde201 ; s896Tg ; tardbplmde114/mde114(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde201/mde201 ; s896Tg ; tardbplmde222/mde222(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde201/mde201 ; tardbplmde114/mde114(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde897/mde897(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbpmde897/mde897 ; tardbplmde114/mde114(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde897/mde897 ; tardbplmde159/mde159(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde897/mde897 ; tardbplmde222/mde222 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde909/mde909(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbpmde909/mde909 ; s896Tg ; tardbplmde159/mde159(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbpmde909/mde909 ; tardbplmde114/mde114(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde909/mde909 ; tardbplmde222/mde222(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde948/mde948(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbpmde948/mde948 ; tardbplmde114/mde114(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde948/mde948 ; tardbplmde159/mde159(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde948/mde948 ; tardbplmde222/mde222(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbpmde948/mde948 ; tardbplmde222/mde222 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbplmde114/mde114(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbplmde114/mde114 ; tardbpmde150/mde150(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbplmde114/mde114 ; tardbpmde198/mde198(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbplmde114/mde114 ; tardbpmde198/mde198 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbplmde114/mde114 ; tardbpmde897/mde897 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbplmde159/mde159(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbplmde159/mde159 ; s896Tg ; tardbpmde150/mde150(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbplmde159/mde159 ; tardbpmde201/mde201(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbplmde159/mde159 ; tardbpmde201/mde201 ; s896Tg(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbplmde159/mde159 ; tardbpmde909/mde909(AB) standard conditions Prim-5 motor neuron axon decreased length, abnormal
Long-pec blood circulation disrupted, abnormal
Long-pec muscle cell degenerate, abnormal
Long-pec nucleate erythrocyte accumulation yolk anatomical surface, abnormal
Long-pec skeletal muscle cell decreased size, abnormal
Long-pec skeletal muscle cell myofibril decreased thickness, abnormal
Long-pec skeletal muscle cell myofibril disorganized, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec trunk musculature mitochondrion mislocalised, abnormal
Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbplmde222/mde222(AB) standard conditions Prim-15 axon extension process quality, normal
Prim-15 motor neuron axon length, normal
tardbplmde222/mde222 ; s896Tg ; tardbpmde150/mde150(AB) standard conditions Long-pec cranial vasculature irregular spatial pattern, abnormal
Long-pec intersegmental vessel decreased functionality, abnormal
Long-pec intersegmental vessel structure, abnormal
Long-pec vascular sprouts increased amount, abnormal
Long-pec vascular sprouts increased branchiness, abnormal
tardbplmde222/mde222 ; tardbpmde198/mde198(AB) standard conditions Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbplmde222/mde222 ; tardbpmde201/mde201(AB) standard conditions Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
tardbplmde222/mde222 ; tardbpmde897/mde897(AB) standard conditions Days 7-13 whole organism dead, abnormal
Days 7-13 whole organism decreased life span, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proc. Natl. Acad. Sci. USA for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA