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General Information
ZIRC
ZFIN ID: ZDB-FIG-161014-11
Flanagan-Steet et al., 2016 - Cathepsin-Mediated Alterations In TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   31(3):535-48 Full text @ J. Bone Miner. Res.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Antibodies:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: Day 4
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Day 4

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP mw29Tg standard conditions Day 4 Meckel's cartilage chondrocyte IHC
Day 4 palatoquadrate cartilage chondrocyte IHC
mw29Tg + MO1-gnptab standard conditions Day 4 Meckel's cartilage chondrocyte IHC
Day 4 palatoquadrate cartilage chondrocyte IHC
y1Tg standard conditions Day 4 ceratohyal cartilage chondrocyte IHC
Day 4 Meckel's cartilage chondrocyte IHC
Day 4 palatoquadrate cartilage chondrocyte IHC
y1Tg + MO1-gnptab standard conditions Day 4 ceratohyal cartilage chondrocyte IHC
Day 4 Meckel's cartilage chondrocyte IHC
Day 4 palatoquadrate cartilage chondrocyte IHC
mCherry hu5910Tg standard conditions Day 4 ceratohyal cartilage chondrocyte IHC
Day 4 Meckel's cartilage chondrocyte IHC
hu5910Tg + MO1-gnptab standard conditions Day 4 ceratohyal cartilage chondrocyte IHC
Day 4 Meckel's cartilage chondrocyte IHC
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-smad IHC y1Tg standard conditions Day 4 Meckel's cartilage chondrocyte
IHC Day 4 palatoquadrate cartilage chondrocyte
IHC y1Tg + MO1-gnptab standard conditions Day 4 Meckel's cartilage chondrocyte
IHC Day 4 palatoquadrate cartilage chondrocyte
Ab2-smad2/3 IHC y1Tg standard conditions Day 4 ceratohyal cartilage chondrocyte
IHC Day 4 Meckel's cartilage chondrocyte
IHC y1Tg + MO1-gnptab standard conditions Day 4 ceratohyal cartilage chondrocyte
IHC Day 4 chondrocyte nucleus
IHC Day 4 Meckel's cartilage chondrocyte
Ab3-smad2 IHC y1Tg standard conditions Day 4 ceratohyal cartilage chondrocyte
IHC Day 4 Meckel's cartilage chondrocyte
IHC y1Tg + MO1-gnptab standard conditions Day 4 ceratohyal cartilage chondrocyte
IHC Day 4 chondrocyte nucleus
IHC Day 4 Meckel's cartilage chondrocyte
Ab11-smad IHC y1Tg standard conditions Day 4 Meckel's cartilage chondrocyte
IHC Day 4 palatoquadrate cartilage chondrocyte
IHC y1Tg + MO1-gnptab standard conditions Day 4 Meckel's cartilage chondrocyte
IHC Day 4 palatoquadrate cartilage chondrocyte
Phenotype Details
Fish Conditions Stage Phenotype
hu5910Tg + MO1-gnptab standard conditions Day 4 ceratohyal cartilage chondrocyte mCherry expression increased amount, abnormal
Day 4 Meckel's cartilage chondrocyte mCherry expression increased amount, abnormal
mw29Tg + MO1-gnptab standard conditions Day 4 Meckel's cartilage chondrocyte EGFP expression decreased amount, abnormal
Day 4 palatoquadrate cartilage chondrocyte EGFP expression decreased amount, abnormal
y1Tg + MO1-gnptab standard conditions Day 4 ceratohyal cartilage chondrocyte Ab2-smad2/3 labeling increased amount, abnormal
Day 4 ceratohyal cartilage chondrocyte ab3-smad2 labeling increased amount, abnormal
Day 4 chondrocyte nucleus Ab2-smad2/3 labeling increased amount, abnormal
Day 4 chondrocyte nucleus ab3-smad2 labeling increased amount, abnormal
Day 4 chondrocyte nucleus ab3-smad2 labeling mislocalised, abnormal
Day 4 chondrocyte nucleus Ab2-smad2/3 labeling mislocalised, abnormal
Day 4 Meckel's cartilage chondrocyte Ab11-smad labeling decreased amount, abnormal
Day 4 Meckel's cartilage chondrocyte ab1-smad labeling decreased amount, abnormal
Day 4 Meckel's cartilage chondrocyte ab3-smad2 labeling increased amount, abnormal
Day 4 Meckel's cartilage chondrocyte Ab2-smad2/3 labeling increased amount, abnormal
Day 4 palatoquadrate cartilage chondrocyte ab1-smad labeling decreased amount, abnormal
Day 4 palatoquadrate cartilage chondrocyte Ab11-smad labeling decreased amount, abnormal
Full text @ J. Bone Miner. Res.