ZFIN ID: ZDB-FIG-150722-6
Patil et al., 2015 - scaRNAs Regulate Splicing and Vertebrate Heart Development. Biochimica et biophysica acta. Molecular basis of disease   1852(8):1619-29 Full text @ BBA Molecular Basis of Disease
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Long-pec

Fig. 6

Heart deformities in MO-injected zebrafish. (A) Lateral views of wild-type and MO-injected embryos at 25 and 50 hpf. Both the snord94 and scarna1 morphants display little developmental delay with bent tail (black dotted curved line) and improperly formed yolk extension (black solid line) at 25 hpf. The pericardial edema (black triangle) and deformed yolk sac were more evident at 50 hpf. (B) Enlarged images of the heart region in wild-type and MO-injected embryos at 72 hpf. The conspicuous pericardial edema (black dotted circle) was observed in snoRNA MO-injected embryos. Gray outline is the atrium, blue outline is the ventricle. Scale bars: 200 ┬Ám.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-scarna1 standard conditions Prim-5 embryo development process quality, normal
Prim-5 extension morphology, abnormal
Prim-5 post-vent region bent, abnormal
Long-pec pericardium edematous, abnormal
Long-pec yolk syncytial layer deformed, abnormal
AB + MO1-snord94 standard conditions Prim-5 embryo development process quality, normal
Prim-5 extension morphology, abnormal
Prim-5 post-vent region bent, abnormal
Long-pec pericardium edematous, abnormal
Long-pec yolk syncytial layer deformed, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Biochimica et biophysica acta. Molecular basis of disease for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Biochimica et biophysica acta. Molecular basis of disease, 1852(8), Patil, P., Kibiryeva, N., Uechi, T., Marshall, J., O'Brien, J.E., Artman, M., Kenmochi, N., Bittel, D.C., scaRNAs Regulate Splicing and Vertebrate Heart Development, 1619-29, Copyright (2015) with permission from Elsevier. Full text @ BBA Molecular Basis of Disease