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Fig. 1

ID

ZDB-FIG-150319-19

Publication

Cheng et al., 2015 - The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis

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Fig. 1

The expression of her2 in developing zebrafish embryos. (A) Schematic illustration of a gastrula stage embryo in lateral view. Prospective epidermis (epi) is green; prospective nervous system (neuro) is blue. an, animal pole; D, dorsal; V, ventral; ve, vegetal pole. (B-M) In situ hybridization analysis of the expression of her2 in the developing nervous system. (C-D) A coronal section of the her2-stained neural ectodermal region (as marked in B) with the double in situ hybridization for her2 (purple) and sox2 (red) and that shows overlapping expression. The expression of her2 was detected by NBT/BCIP and sox2 was detected by Fast Red. The stages of the embryos are shown in the bottom left corner of each panel. (B, E, G, I, K, and M) Dorsal views, with anterior to the left. (F, H, J, and L) Lateral view, anterior to the left. Arrows in E indicate her2 expressing cells in the proneuronal domains. The square bracket in J indicates the zona limitans intrathalamica (zli). Abbreviations: ce, cerebellum; dt, dorsal telencephalon; hb, hindbrain; mb, midbrain; mhb, midbrain-hindbrain boundary; psm, presomitic mesoderm; sc, spinal cord; tec, tectum; tel, telencephalon; th, thalamus; vt, ventral telencephalon; vpt, ventral-posterior telencephalon.

Expression Data

Genes:	her2 sox2
Fish:	TU
Anatomical Terms:	cerebellum dorsal telencephalon hindbrain hindbrain neural rod midbrain midbrain hindbrain boundary neural keel neural keel neuroblast neuroectoderm optic tectum posterior neural rod segmental plate spinal cord spinal cord neural tube telencephalon telencephalon postero-ventral region thalamus ventral telencephalon
Stage Range:	75%-epiboly to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 397(1), Cheng, Y.C., Chiang, M.C., Shih, H.Y., Ma, T.L., Yeh, T.H., Huang, Y.C., Lin, C.Y., Lin, S.J., The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis, 116-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.