ZFIN ID: ZDB-GENE-980526-274
Gene Name: hairy-related 2
Gene Symbol: her2    Nomenclature History

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Previous Name: Hes5a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II and neurogenesis. Localizes to chromatin. Is expressed in several structures, including central nervous system; ciliary marginal zone; neural keel; posterior neural rod; and spinal cord neural tube. Orthologous to human HES5 (hes family bHLH transcription factor 5).
Genome Resources: Alliance (1),  Gene:30300 (1),  Ensembl(GRCz11):ENSDARG00000038205 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012040Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa49 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35155 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-her2 N/A 1
    MO2-her2 N/A 1
    MO3-her2 N/A 1
    DISEASE ASSOCIATED WITH her2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH her2 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA her2-201 (1)    Ensembl 774
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM her2 No data available
    MARKER RELATIONSHIPS
    her2 Contained in: [Fosmid] ZFOS-1132D4 (1)
    her2 Contains: [SNP] rs3728405 (1), rs3728406 (1), rs3728407 (1)
    her2 Encodes: [cDNA] MGC:194404 (1), MGC:194440 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131089 (1) 741 nt
    Genomic GenBank:CU633737 (1) 27522 nt
    Select Tool
    Polypeptide UniProtKB:Q90464 (1) 108 aa
    Sequence Information (all 19)
    ORTHOLOGY for her2 ( Chr: 11 )
    CITATIONS (57)