Gene

her2

ID
ZDB-GENE-980526-274
Name
hairy-related 2
Symbol
her2 Nomenclature History
Previous Names
  • Hes5a (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of transcription, DNA-templated; and neurogenesis. Located in chromatin. Is expressed in several structures, including central nervous system; ciliary marginal zone; neural keel; posterior neural rod; and spinal cord neural tube. Orthologous to human HES5 (hes family bHLH transcription factor 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With her2 Human Ortholog
No data available
Associated With her2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003650 Orange domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Orange domain
UniProtKB:Q90464 108
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations