FIGURE

Fig. 6

ID

ZDB-FIG-140806-10

Publication

Teng et al., 2013 - Evaluating human cancer cell metastasis in zebrafish

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Fig. 6

Suppression of invasion in vitro leads to suppression of metastasis in zebrafish following loss of JAK1 or JAK2 expression. Western blot analysis confirmed JAK-deficiencies in U4C and γ 2A cells (a). When human 2C4 fibrosarcoma cells are injected into zebrafish (b, left) (shown as z-stack images using 40× magnification), extensive spread throughout the body of the fish can be seen over 120 hpi. This metastasis potential correlates with in vitro invasion (b, right). In both JAK1-deficient U4C cells and JAK2-deficient γ2A cells, reduced levels of metastatic spread are seen (c, left), which correlates with reduced invasion in vitro (c, right).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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