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ZIRC
ZFIN ID: ZDB-FIG-140214-42
Valvezan et al., 2014 - Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Disease models & mechanisms   7(1):63-71 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Long-pec

Fig. 5

Combined inhibition of mTORC1 and Wnt signaling reduces body curvature in apcmcr/mcr zebrafish. (A) Representative images of apcmcr/mcr zebrafish at 2 dpf treated with vehicle, Torin1 (250 nM), XAV939 (500 nM) or Torin1 plus XAV939. Combined Torin1 and XAV939 treatment rescued body curvature whereas either treatment alone did not. (B) Zebrafish were scored at 2-3 dpf on the basis of severity of body curvature; the percentage of fish in each category is shown. Only combined Torin1 plus XAV939 treatment reduced body curvature. (C) Rapamycin also reduced body curvature in combination with XAV939, but not by itself. (D) Representative pictures of each of the three categories used to score body curvature in B and C.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
apchu745/hu745 standard conditions Long-pec anterior/posterior axis specification process quality, abnormal
Long-pec whole organism curved, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.