ZFIN ID: ZDB-FIG-140214-37
Activation of mTORC1 in apcmcr/mcr zebrafish. Western blot analysis using antibodies to phosphorylated S6 (p-S6), indicating mTORC1 activity, or total S6 on whole embryo lysates from pooled wild-type and heterozygous apcmcr/+ zebrafish or homozygous apcmcr/mcr zebrafish at 3 or 4 dpf. mTORC1 activity was increased in the homozygous apcmcr/mcr zebrafish. (B) Immunohistochemical staining of sagittal sections from wild-type or homozygous apcmcr/mcr zebrafish at 3 dpf using antibodies to phosphorylated or total S6 and counterstaining with DAPI. mTORC1 was aberrantly active in multiple mesodermal and endodermal derivatives in the homozygous apcmcr/mcr zebrafish.
Gene Expression DetailsNo data available
Antibody Labeling Details
Phenotype Details No data available
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