ZFIN ID: ZDB-FIG-140214-40
mTORC1 inhibition improves circulation in apcmcr/mcr zebrafish. (A) apcmcr/mcr zebrafish were treated with vehicle or Torin1 (250 nM) and the rate of blood flow through the dorsal aorta was measured using high speed videomicroscopy in unanesthetized larvae at 2-3 dpf. Blood flow phenotypes were categorized according to flow rate as indicated. Representative movies for each scoring category can be found in online supplementary material (supplementary material Movies 1-4). (B) Rapamycin also improved circulation in apcmcr/mcr zebrafish. (C,D) Torin1 and rapamycin treatment did not increase the heart rate of apcmcr/mcr zebrafish.
Gene Expression DetailsNo data available
Antibody Labeling Details No data available
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