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General Information
ZIRC
ZFIN ID: ZDB-FIG-140214-40
Valvezan et al., 2014 - Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Disease models & mechanisms   7(1):63-71 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Protruding-mouth

Fig. 3

mTORC1 inhibition improves circulation in apcmcr/mcr zebrafish. (A) apcmcr/mcr zebrafish were treated with vehicle or Torin1 (250 nM) and the rate of blood flow through the dorsal aorta was measured using high speed videomicroscopy in unanesthetized larvae at 2-3 dpf. Blood flow phenotypes were categorized according to flow rate as indicated. Representative movies for each scoring category can be found in online supplementary material (supplementary material Movies 1-4). (B) Rapamycin also improved circulation in apcmcr/mcr zebrafish. (C,D) Torin1 and rapamycin treatment did not increase the heart rate of apcmcr/mcr zebrafish.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
apchu745/hu745 standard conditions Long-pec - Protruding-mouth dorsal aorta blood decreased fluid flow, abnormal
Long-pec - Protruding-mouth dorsal aorta blood circulation decreased process quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.