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ZFIN ID: ZDB-FIG-130820-585
Li et al., 2013 - Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development (Cambridge, England)   140(14):3028-3039 Full text @ Development
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 4 gpr125 interacts with scrb1/llk and vangl2/tri in FBMN migration. (A-C) Dorsal views of islet1(isl1):GFP-expressing neurons in uninjected, 3.4 ng control MO or 3.4 ng MO2-gpr125 injected wild-type siblings of scrb1/llk or vangl2/tri heterozygous embryos at 48 hpf. Anterior is upwards. r4 (rhombomere 4), r5 and r6 positions are labeled. (D) Frequency of FBMN migration phenotypic classes observed in wild-type embryos. Blue, normal; yellow, partial; red, no migration. (E-H) Dorsal views of isl1:GFP-expressing neurons in uninjected, 3.4 ng control MO or 3.4 ng MO2-gpr125-injected scrb1/llkrw468/+ embryos at 48 hpf. (I) Frequency of the FBMN migration phenotypic classes observed in scrb1/llkrw468/+ embryos. (J-N) Dorsal views of isl1:GFP-expressing neurons in uninjected, 3.4 ng control MO or 3.4 ng MO2-gpr125-injected vangl2/trivu67/+ embryos at 48 hpf. (O) Frequency of FBMN migration phenotypic classes observed in vangl2/trivu67/+ heterozygotes.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
scribrw468/+; rw0Tg + MO2-adgra3 standard conditions Long-pec branchiomotor neuron located in rhombomere 4, abnormal
Long-pec motor neuron migration disrupted, abnormal
vangl2vu67/+; rw0Tg + MO2-adgra3 standard conditions Long-pec branchiomotor neuron located in rhombomere 4, abnormal
Long-pec motor neuron migration disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development