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ZIRC
ZFIN ID: ZDB-FIG-121102-36
Zhang et al., 2010 - Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America   107(39):16940-16945 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 4

Overexpression of fgf8a synergizes with mutation of p53 in MPNST development. Kaplan–Meier curves indicate when externally visible tumors were first observed in fish with the indicated genotypes. All fish were progeny of the same four pairs born the same day. Tumor type was confirmed by histological analysis, and fish with neuroblastoma (1 in p53 HOM, HagD1 het, 1 in p53 het, HagD1 het) were excluded from the analysis. No MPNSTs were found in p53 WT, HagD1 heterozygous fish. P values comparing genotyped pairs are shown.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
tp53zdf1/+ standard conditions Adult peripheral nervous system neurofibrosarcoma increased amount, abnormal
tp53zdf1/+; fbxw4dhiD1Tg/+ standard conditions Adult peripheral nervous system neurofibrosarcoma increased amount, abnormal
tp53zdf1/zdf1 standard conditions Adult peripheral nervous system neurofibrosarcoma increased amount, abnormal
tp53zdf1/zdf1; fbxw4dhiD1Tg/+ standard conditions Adult peripheral nervous system neurofibrosarcoma increased amount, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proceedings of the National Academy of Sciences of the United States of America for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA