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ZFIN ID: ZDB-FIG-091215-51
Alvarez et al., 2009 - Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase. PLoS One   4(11):e7867 Full text @ PLoS One
Observed In:
Stage: Adult

Fig. 6 LY294002 attenuates Regenerative Angiogenesis in Adult Zebrafish.

The caudal fins of adult Tg(fli1:EGFP) zebrafish were amputated and left to regenerate in either tank water or tank water supplemented with 10 μM LY294002. Bight field micrographs (A) or fluorescent micrographs (B) of representative fins at 9 days post-amputation are shown. The maximal, average blood vessel length in the regenerated tissue was quantified at the third fin ray in either fin lobe and the results are depicted in (C). LY294002 significantly inhibits regenerative angiogenesis in the tail fin (** p<0.01, t-test). Yellow lines in B indicate the amputation plane. n = 8 fin rays in 4 fish. Scale bars = 500 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
y1Tg amputation: caudal fin, chemical treatment: LY294002 Adult angiogenesis involved in wound healing disrupted, abnormal
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