ZFIN ID: ZDB-FIG-080516-24
Shin et al., 2008 - Multiple roles for Med12 in vertebrate endoderm development. Developmental Biology   317(2):467-479 Full text @ Dev. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage: Day 4
PHENOTYPE:
Fish:
Observed In:
Stage: Day 4

Fig. S2 shr is required for ventral pancreas development. Confocal projections of wild-type and shrs435 mutant larvae in the Tg(fabp1a:dsRed, elastase:GFP; insulin:dsRed) line at 96 hpf. (A, A′) shrs435 mutant larvae show multiple Tg(elastase: GFP)-positive ventral pancreatic buds (white arrowheads), and defective elongation of the ventral pancreatic tail (white arrow). Despite defective hepatic differentiation, a population of liver cells expresses DsRed in the mutant larvae. All images are ventral views, anterior to the top.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
DsRed gz2Tg; gz4Tg; m1018Tg standard conditions Day 4 endocrine pancreas IFL
Day 4 liver IFL
med12s435/s435; gz2Tg; gz4Tg; m1018Tg standard conditions Day 4 endocrine pancreas IFL
Day 4 liver IFL
GFP gz2Tg; gz4Tg; m1018Tg standard conditions Day 4 exocrine pancreas IFL
med12s435/s435; gz2Tg; gz4Tg; m1018Tg standard conditions Day 4 exocrine pancreas IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
med12s435/s435; gz2Tg; gz4Tg; m1018Tg standard conditions Day 4 endodermal cell fate specification disrupted, abnormal
Day 4 exocrine pancreas development disrupted, abnormal
Day 4 exocrine pancreas increased amount, abnormal
Day 4 exocrine pancreas morphology, abnormal
Day 4 liver decreased size, abnormal
Day 4 liver morphology, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 317(2), Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y., Multiple roles for Med12 in vertebrate endoderm development, 467-479, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.