ZFIN is now using GRCz12tu for Genomic Data
Gene
tjp1a
- ID
- ZDB-GENE-031001-2
- Name
- tight junction protein 1a
- Symbol
- tjp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to be located in gap junction. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 53 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb817 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000906 | ZU5 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR035597 | ZO-1, SH3 domain |
| Family | IPR005417 | Tight junction protein ZO |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tjp1a-201
(1)
|
Ensembl | 4,902 nt | ||
| mRNA |
tjp1a-202
(1)
|
Ensembl | 6,999 nt | ||
| mRNA |
tjp1a-203
(1)
|
Ensembl | 676 nt | ||
| mRNA |
tjp1a-204
(1)
|
Ensembl | 612 nt | ||
| mRNA |
tjp1a-205
(1)
|
Ensembl | 485 nt | ||
| mRNA |
tjp1a-206
(1)
|
Ensembl | 1,035 nt | ||
| mRNA |
tjp1a-207
(1)
|
Ensembl | 544 nt | ||
| mRNA |
tjp1a-209
(1)
|
Ensembl | 206 nt | ||
| mRNA |
tjp1a-210
(1)
|
Ensembl | 784 nt | ||
| mRNA |
tjp1a-211
(1)
|
Ensembl | 5,101 nt | ||
| mRNA |
tjp1a-212
(1)
|
Ensembl | 5,074 nt | ||
| ncRNA |
tjp1a-004
(1)
|
Ensembl | 751 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tjp1 | monoclonal | IgG1 , k | Mouse |
|
Life Technologies (Invitrogen)
Thermo Fisher Scientific (Lab Vision) |
250 | |
| Ab2-tjp1 | polyclonal | Rabbit |
|
Life Technologies (Invitrogen)
|
24 | ||
| Ab5-tjp1a | polyclonal | Rabbit |
|
2 | |||
| Ab4-tjp1a | polyclonal | Rabbit |
|
1 |
Plasmids
No data available
- Genome Browsers