Gene
cryaa
- ID
- ZDB-GENE-020508-1
- Name
- crystallin, alpha A
- Symbol
- cryaa Nomenclature History
- Previous Names
-
- [a]A-crystallin (1)
- hspb4
- wu:fc06h04
- zgc:92036
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Exhibits unfolded protein binding activity. Involved in lens development in camera-type eye. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is expressed in eye; lens; and solid lens vesicle. Orthologous to several human genes including CRYAA2 (crystallin alpha A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92036 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 9 multiple types | Alliance | Cataract 9, multiple types | 604219 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | cryaavu532/vu532 | standard conditions | Zou et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alpha crystallin/Hsp20 domain | Alpha-crystallin, N-terminal | Alpha crystallin/Small heat shock protein, animal type | HSP20-like chaperone |
|---|---|---|---|---|---|
|
UniProtKB:Q8UUZ6
|
173 |
Interactions and Pathways
No data available
Plasmids