ZFIN

ZFIN ID: ZDB-GENE-121113-1

CITATIONS (37 total)

Gene Name:	pregnancy-associated plasma protein A, pappalysin 1a
Gene Symbol:	pappaa

Wang, Z., Shah, J., Li, S., Jaggi, S., Xu, H., Duan, C. (2026) Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxic stress. Frontiers in endocrinology. 16:17296491729649

Schloss, S.S., Marshall, Z.Q., Santistevan, N.J., Gjorcheska, S., Stenzel, A., Barske, L., Nelson, J.C. (2025) Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling. PLoS Biology. 23:e3003164e3003164

Harboe, M., Kjaer-Sorensen, K., Füchtbauer, E.M., Fenton, R.A., Thomsen, J.S., Brüel, A., Oxvig, C. (2024) The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization. Scientific Reports. 14:2016120161

Li, Y., Liu, C., Rolling, L., Sikora, V., Chen, Z., Gurwin, J., Barabell, C., Lin, J., Duan, C. (2023) ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Proceedings of the National Academy of Sciences of the United States of America. 120:e2216310120e2216310120

Nelson, J.C., Shoenhard, H., Granato, M. (2023) Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity. PLoS Genetics. 19:e1010650e1010650

Yoon, B., Yeung, P., Santistevan, N., Bluhm, L., Kawasaki, K., Kueper, J., Dubielzig, R., Vanoudenhove, J., Cotney, J., Liao, E.C., Grinblat, Y. (2022) Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Biology Open. 11(5):

Alassaf, M., Halloran, M.C. (2021) Pregnancy associated plasma protein-aa regulates endoplasmic reticulum-mitochondria associations. eLIFE. 10:

Li, S., Liu, C., Goldstein, A., Xin, Y., Ke, C., Duan, C. (2021) Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Frontiers in cell and developmental biology. 9:662915

Demirci, Y., Cucun, G., Poyraz, Y.K., Mohammed, S., Heger, G., Papatheodorou, I., Ozhan, G. (2020) Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Frontiers in cell and developmental biology. 8:584604

Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A.K., Goldstein, A., Ke, C., Oxvig, C., Duan, C. (2020) The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition. eLIFE. 9:

Nelson, J.C., Witze, E., Ma, Z., Ciocco, F., Frerotte, A., Randlett, O., Foskett, J.K., Granato, M. (2020) Acute Regulation of Habituation Learning via Posttranslational Palmitoylation. Current biology : CB. 30(14):2729-2738.e4

Alassaf, M., Daykin, E.C., Mathiaparanam, J., Wolman, M.A. (2019) Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function. eLIFE. 8:

Bremer, J., Marsden, K.C., Miller, A., Granato, M. (2019) The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology. 2:195

Miller, A.H., Howe, H.B., Krause, B.M., Friedle, S.A., Banks, M.I., Perkins, B.D., Wolman, M.A. (2018) Pregnancy associated plasma protein-aa (Pappaa) regulates photoreceptor synaptic development to mediate visually guided behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(22):5220-5236

Sugden, W.W., Meissner, R., Aegerter-Wilmsen, T., Tsaryk, R., Leonard, E.V., Bussmann, J., Hamm, M.J., Herzog, W., Jin, Y., Jakobsson, L., Denz, C., Siekmann, A.F. (2017) Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology. 19(6):653-665

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Giousoh, A., Vaz, R., Bryson-Richardson, R.J., Whisstock, J.C., Verkade, H., Bird, P.I. (2015) Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Gene expression patterns : GEP. 18(1-2):37-43

Wolman, M.A., Jain, R.A., Marsden, K.C., Bell, H., Skinner, J., Hayer, K.E., Hogenesch, J.B., Granato, M. (2015) A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron. 85(6):1200-11

Kjaer-Sorensen, K., Engholm, D.H., Kamei, H., Morch, M.G., Kristensen, A.O., Zhou, J., Conover, C.A., Duan, C., and Oxvig, C. (2013) Pregnancy-associated plasma protein-A (PAPP-A) modulates early developmental rate in zebrafish independent of its proteolytic activity. The Journal of biological chemistry. 288(14):9982-92

Additional Citations (18):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.