ZFIN is now using GRCz12tu for Genomic Data
Gene
pappaa
- ID
- ZDB-GENE-121113-1
- Name
- pregnancy-associated plasma protein A, pappalysin 1a
- Symbol
- pappaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within chondrocyte differentiation and habituation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in CNS interneuron; Meckel's cartilage; and cranial ganglion. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000800 | Notch domain |
| Domain | IPR006558 | LamG-like jellyroll fold |
| Domain | IPR008754 | Peptidase M43, pregnancy-associated plasma-A |
| Domain | IPR058897 | Pappalysin-1, SD scarf domain, C-terminal |
| Family | IPR043543 | Pappalysin-1/2 |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Repeat | IPR011936 | Myxococcus cysteine-rich repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Fibronectin type III superfamily | LamG-like jellyroll fold | Metallopeptidase, catalytic domain superfamily | Myxococcus cysteine-rich repeat | Notch domain | Pappalysin-1/2 | Pappalysin-1, SD scarf domain, C-terminal | Peptidase M43, pregnancy-associated plasma-A | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:M1XYM1 | InterPro | 1629 | |||||||||||
| UniProtKB:A0AC58JH30 | InterPro | 1649 | |||||||||||
| UniProtKB:A0AC58JH32 | InterPro | 1410 | |||||||||||
| UniProtKB:A0AC58JH46 | InterPro | 1646 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pappaa-201
(1)
|
Ensembl | 5,582 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers