Gene

pappaa

ID

ZDB-GENE-121113-1

Name

pregnancy-associated plasma protein A, pappalysin 1a

Symbol

pappaa Nomenclature History

Previous Names

papp-a' (1)
unfiltered (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Involved in several processes, including habituation; insulin-like growth factor receptor signaling pathway; and visual behavior. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in Mauthner neurons; anterior lateral line ganglion; hindbrain interneuron; posterior lateral line ganglion; and statoacoustic (VIII) ganglion. Orthologous to human PAPPA (pappalysin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pappaa Human Ortholog

No data available

Associated With pappaa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR000800	Notch domain
Domain	IPR006558	LamG-like jellyroll fold
Domain	IPR008754	Peptidase M43, pregnancy-associated plasma-A
Family	IPR043543	Pappalysin-1/2
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Repeat	IPR011936	Myxococcus cysteine-rich repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	Fibronectin type III superfamily	LamG-like jellyroll fold	Metallopeptidase, catalytic domain superfamily	Myxococcus cysteine-rich repeat	Notch domain	Pappalysin-1/2	Peptidase M43, pregnancy-associated plasma-A	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily
UniProtKB:M1XYM1 InterPro	1629

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations