Gene

pappaa

ID
ZDB-GENE-121113-1
Name
pregnancy-associated plasma protein A, pappalysin 1a
Symbol
pappaa Nomenclature History
Previous Names
  • papp-a' (1)
  • unfiltered (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Involved in several processes, including habituation; insulin-like growth factor receptor signaling pathway; and visual behavior. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in Mauthner neurons; anterior lateral line ganglion; hindbrain interneuron; posterior lateral line ganglion; and statoacoustic (VIII) ganglion. Orthologous to human PAPPA (pappalysin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pappaa Human Ortholog
No data available
Associated With pappaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR000800 Notch domain
Domain IPR006558 LamG-like jellyroll fold
Domain IPR008754 Peptidase M43, pregnancy-associated plasma-A
Family IPR043543 Pappalysin-1/2
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Repeat IPR011936 Myxococcus cysteine-rich repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily Fibronectin type III superfamily LamG-like jellyroll fold Metallopeptidase, catalytic domain superfamily Myxococcus cysteine-rich repeat Notch domain Pappalysin-1/2 Peptidase M43, pregnancy-associated plasma-A Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily
UniProtKB:M1XYM1 1629
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations