ZFIN

ZFIN ID: ZDB-GENE-080204-52

ZFIN ID: ZDB-GENE-080204-52

CITATIONS (59 total)

Gene Name:	ATP-binding cassette, sub-family B (MDR/TAP), member 4
Gene Symbol:	abcb4

Lim, M.Y., Bernier, N.J. (2023) Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish. The Journal of experimental biology. 226(16):

Park, J., Kim, H., Alabdalla, L., Mishra, S., Mchaourab, H. (2023) Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein. Human genomics. 17:8484

Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436

Lim, M.Y., Bernier, N.J. (2022) Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol. The Journal of experimental biology. 225(21):

Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417

Wang, S., Bao, J., Li, J., Li, W., Tian, M., Qiu, C., Pang, F., Li, X., Yang, J., Hu, Y., Wang, S., Jin, H. (2022) Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway. Molecules. 27(9):

Robey, R.W., Robinson, A.N., Ali-Rahmani, F., Huff, L.M., Lusvarghi, S., Vahedi, S., Hotz, J.M., Warner, A.C., Butcher, D., Matta, J., Edmondson, E.F., Lee, T.D., Roth, J.S., Lee, O.W., Shen, M., Tanner, K., Hall, M.D., Ambudkar, S.V., Gottesman, M.M. (2021) Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter. Scientific Reports. 11:24150

Bieczynski, F., Burkhardt-Medicke, K., Marcelo Luquet, C., Scholz, S., Luckenbach, T. (2020) Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity. FEBS letters. 595(6):828-843

Ma, Y.N., Sun, L.H., Li, S.Y., Ni, Y.X., Cao, Z.Y., Chen, M.X., Mou, R.X. (2020) Modulation of steroid metabolism and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to triadimefon. Environmental pollution (Barking, Essex : 1987). 262:114145

Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171

Zou, W., Xia, M., Jiang, K., Cao, Z., Zhang, X., Hu, X. (2020) Photo-Oxidative Degradation Mitigated the Developmental Toxicity of Polyamide Microplastics to Zebrafish Larvae by Modulating Macrophage-Triggered Proinflammatory Responses and Apoptosis. Environmental science & technology. 54(21):13888-13898

Fernanda Moreira, L., Juliana Zomer, S., Marta Marques, S. (2019) Modulation of the multixenobiotic resistance mechanism in Danio rerio hepatocyte culture (ZF-L) after exposure to glyphosate and Roundup^®. Chemosphere. 228:159-165

Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117

Hu, J., Tian, J., Zhang, F., Wang, H., Yin, J. (2019) Pxr- and Nrf2- mediated induction of ABC transporters by heavy metal ions in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 255:113329

Tian, J., Hu, J., Liu, G., Yin, H., Chen, M., Miao, P., Bai, P., Yin, J. (2018) Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots. Environmental pollution (Barking, Essex : 1987). 244:588-599

Verbueken, E., Bars, C., Ball, J.S., Periz-Stanacev, J., Marei, W.F.A., Tochwin, A., Gabriëls, I.J., Michiels, E.D.G., Stinckens, E., Vergauwen, L., Knapen, D., Van Ginneken, C.J., Van Cruchten, S.J. (2018) From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development. International Journal of Molecular Sciences. 19(12)

Yan, Z., Sun, H., Jiang, R., Dong, H., Yang, H., Liu, J., Lu, G., Ji, Y. (2018) Accumulation, metabolite and active defence system responses of fluoxetine in zebrafish embryos: Influence of multiwalled carbon nanotubes with different functional groups. Aquatic toxicology (Amsterdam, Netherlands). 205:204-212

Zheng, M., Lu, J., Zhao, D. (2018) Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Scientific Reports. 8:8083

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Carmona-Antoñanzas, G., Santi, M., Migaud, H., Vera, L.M. (2017) Light- and clock-control of genes involved in detoxification. Chronobiology International. 34(8):1026-1041

Cunha, V., Burkhardt-Medicke, K., Wellner, P., Santos, M.M., Moradas-Ferreira, P., Luckenbach, T., Ferreira, M. (2017) Effects of pharmaceuticals and personal care products (PPCPs) on multixenobiotic resistance (MXR) related efflux transporter activity in zebrafish (Danio rerio) embryos. Ecotoxicology and environmental safety. 136:14-23

Ellis, J.L., Bove, K.E., Schuetz, E.G., Leino, D., Valencia, C.A., Schuetz, J.D., Miethke, A., Yin, C. (2017) Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency. Hepatology (Baltimore, Md.). 67(4):1531-1545

Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967

Jackson, J.S., Kennedy, C.J. (2017) Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 200:34-41

Mottaz, H., Schönenberger, R., Fischer, S., Eggen, R.I., Schirmer, K., Groh, K.J. (2017) Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environmental pollution (Barking, Essex : 1987). 221:105-115

Tian, J., Hu, J., Chen, M., Yin, H., Miao, P., Bai, P., Yin, J. (2017) The use of mrp1-deficient (Danio rerio) zebrafish embryos to investigate the role of Mrp1 in the toxicity of cadmium chloride and benzo[a]pyrene. Aquatic toxicology (Amsterdam, Netherlands). 186:123-133

Zheng, M., Lu, J., Zhao, D. (2017) Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. The Science of the total environment. 622-623:930-941

Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2016) Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquatic toxicology (Amsterdam, Netherlands). 178:182-189

Cunha, V., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2016) Simvastatin effects on detoxification mechanisms in Danio rerio embryos. Environmental science and pollution research international. 23(11):10615-29

Keiter, S., Burkhard-Medicke, K., Wellner, P., Kais, B., Färber, H., Skutlarek, D., Engwall, M., Braunbeck, T., Keiter, S.H., Luckenbach, T. (2016) Does perfluorooctane sulfonate (PFOS) act as chemosensitizer in zebrafish embryos?. The Science of the total environment. 548-549:317-324

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Jaumot, J., Navarro, A., Faria, M., Barata, C., Tauler, R., Piña, B. (2015) qRT-PCR evaluation of the transcriptional response of zebra mussel to heavy metals. BMC Genomics. 16:354

Lu, X., Long, Y., Sun, R., Zhou, B., Lin, L., Zhong, S., Cui, Z. (2015) Zebrafish Abcb4 is a potential efflux transporter of microcystin-LR. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 167:35-42

Nornberg, B.F., Batista, C.R., Almeida, D.V., Trindade, G.S., Marins, L.F. (2015) ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Toxicology in vitro : an international journal published in association with BIBRA. 29(1):204-10

Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Fischer, S., Klüver, N., Burkhardt-Medicke, K., Pietsch, M., Schmidt, A.M., Wellner, P., Schirmer, K., and Luckenbach, T. (2013) Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos. BMC Biology. 11(1):69

Fleming, A., Diekmann, H., and Goldsmith, P. (2013) Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One. 8(10):e77548

Long, Y., Li, Q., Wang, Y., and Cui, Z. (2011) MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 153(3):310-317

Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300

Annilo, T., Chen, Z.Q., Shulenin, S., Costantino, J., Thomas, L., Lou, H., Stefanov, S., and Dean, M. (2006) Evolution of the vertebrate ABC gene family: Analysis of gene birth and death. Genomics. 88(1):1-11

Dean, M., and Annilo, T. (2005) Evolution of the ATP-Binding Cassette (ABC) Transporter Superfamily in Vertebrates. Annual review of genomics and human genetics. 6:123-142

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (16):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.