Gene
abcb4
- ID
- ZDB-GENE-080204-52
- Name
- ATP-binding cassette, sub-family B (MDR/TAP), member 4
- Symbol
- abcb4 Nomenclature History
- Previous Names
-
- abcb1b (1)
- zgc:172149
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables ABC-type protein transporter activity; efflux transmembrane transporter activity; and toxin transmembrane transporter activity. Acts upstream of or within response to toxic substance. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in digestive system; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Fischer et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-abcb4 | N/A | Fischer et al., 2013 |
| MO2-abcb4 | N/A | Fischer et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cholecystitis | Alliance | Gallbladder disease 1 | 600803 |
| inflammatory bowel disease 13 | Alliance | {Inflammatory bowel disease 13} | 612244 |
| intrahepatic cholestasis of pregnancy 3 | Alliance | Cholestasis, intrahepatic, of pregnancy, 3 | 614972 |
| progressive familial intrahepatic cholestasis 3 | Alliance | Cholestasis, progressive familial intrahepatic 3 | 602347 |
| Encephalopathy, acute transient | 620950 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR039421 | Type 1 protein exporter |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F1E3 | InterPro | 1275 | |||||||
| UniProtKB:A0A8N1TR42 | InterPro | 650 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-abcb4 | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-215G1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-24I24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172149 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001316714 (1) | 4535 nt | ||
| Genomic | GenBank:BX322614 (2) | 199783 nt | ||
| Polypeptide | UniProtKB:E7F1E3 (1) | 1275 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ABCB1 | 7 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
| Human | ABCB4 | 7 | Amino acid sequence comparison (4) Conserved genome location (synteny) (3) | |
| Mouse | Abcb1a | 5 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) | |
| Mouse | Abcb1b | 5 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) | |
| Mouse | Abcb4 | 5 | Amino acid sequence comparison (3) Conserved genome location (synteny) (1) |
- Lim, M.Y., Bernier, N.J. (2023) Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish. The Journal of experimental biology. 226(16):
- Park, J., Kim, H., Alabdalla, L., Mishra, S., Mchaourab, H. (2023) Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein. Human genomics. 17:8484
- Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436
- Lim, M.Y., Bernier, N.J. (2022) Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol. The Journal of experimental biology. 225(21):
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Wang, S., Bao, J., Li, J., Li, W., Tian, M., Qiu, C., Pang, F., Li, X., Yang, J., Hu, Y., Wang, S., Jin, H. (2022) Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway. Molecules. 27(9):
- Robey, R.W., Robinson, A.N., Ali-Rahmani, F., Huff, L.M., Lusvarghi, S., Vahedi, S., Hotz, J.M., Warner, A.C., Butcher, D., Matta, J., Edmondson, E.F., Lee, T.D., Roth, J.S., Lee, O.W., Shen, M., Tanner, K., Hall, M.D., Ambudkar, S.V., Gottesman, M.M. (2021) Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter. Scientific Reports. 11:24150
- Bieczynski, F., Burkhardt-Medicke, K., Marcelo Luquet, C., Scholz, S., Luckenbach, T. (2020) Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity. FEBS letters. 595(6):828-843
- Ma, Y.N., Sun, L.H., Li, S.Y., Ni, Y.X., Cao, Z.Y., Chen, M.X., Mou, R.X. (2020) Modulation of steroid metabolism and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to triadimefon. Environmental pollution (Barking, Essex : 1987). 262:114145
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
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