Gene

abcb4

ID

ZDB-GENE-080204-52

Name

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Symbol

abcb4 Nomenclature History

Previous Names

abcb1b (1)
zgc:172149

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Exhibits ATPase-coupled protein transmembrane transporter activity; efflux transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in response to toxic substance. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cholestasis (multiple); inflammatory bowel disease (multiple); leukemia (multiple); and liver disease (multiple). Is expressed in digestive system and head. Orthologous to several human genes including ABCB4 (ATP binding cassette subfamily B member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Fischer et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abcb4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cholecystitis	Alliance	Gallbladder disease 1	600803
inflammatory bowel disease 13	Alliance	{Inflammatory bowel disease 13}	612244
intrahepatic cholestasis of pregnancy 3	Alliance	Cholestasis, intrahepatic, of pregnancy, 3	614972
progressive familial intrahepatic cholestasis 3	Alliance	Cholestasis, progressive familial intrahepatic 3	602347
		Encephalopathy, acute transient	620950
		{Colchicine resistance}	120080

Associated With abcb4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011527	ABC transporter type 1, transmembrane domain
Family	IPR039421	Type 1 protein exporter
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036640	ABC transporter type 1, transmembrane domain superfamily