PUBLICATION
Evolution of the vertebrate ABC gene family: Analysis of gene birth and death
- Authors
- Annilo, T., Chen, Z.Q., Shulenin, S., Costantino, J., Thomas, L., Lou, H., Stefanov, S., and Dean, M.
- ID
- ZDB-PUB-060501-5
- Date
- 2006
- Source
- Genomics 88(1): 1-11 (Journal)
- Registered Authors
- Chen, Z. Q., Lou, Hong
- Keywords
- ATP-binding cassette, transporter, evolution, lipid transport, drug resistance, cystic fibrosis, adrenoleukodystrophy
- MeSH Terms
-
- ATP-Binding Cassette Transporters/genetics*
- Animals
- Base Sequence
- Chickens/genetics
- Ciona intestinalis/genetics
- Dogs/genetics
- Evolution, Molecular*
- Gene Deletion*
- Gene Duplication*
- Genome
- Genome, Human
- Humans
- Models, Genetic
- Molecular Sequence Data
- Phylogeny
- Sequence Alignment
- Zebrafish/genetics
- PubMed
- 16631343 Full text @ Genomics
Citation
Annilo, T., Chen, Z.Q., Shulenin, S., Costantino, J., Thomas, L., Lou, H., Stefanov, S., and Dean, M. (2006) Evolution of the vertebrate ABC gene family: Analysis of gene birth and death. Genomics. 88(1):1-11.
Abstract
Vertebrate evolution has been largely driven by the duplication of genes that allow for the acquisition of new functions. The ATP-binding cassette (ABC) proteins constitute a large and functionally diverse family of membrane transporters. The members of this multigene family are found in all cellular organisms, most often engaged in the translocation of a wide variety of substrates across lipid membranes. Because of the diverse function of these genes, their large size, and the large number of orthologs, ABC genes represent an excellent tool to study gene family evolution. We have identified ABC proteins from the sea squirt (Ciona intestinalis), zebrafish (Danio rerio), and chicken (Gallus gallus) and, using phylogenetic analysis, identified those genes with a one-to-one orthologous relationship to human ABC proteins. All ABC protein subfamilies found in Ciona and zebrafish correspond to the human subfamilies, with the exception of a single ABCH subfamily gene found only in zebrafish. Multiple gene duplication and deletion events were identified in different lineages, indicating an ongoing process of gene evolution. As many ABC genes are involved in human genetic diseases, and important drug transport phenotypes, the understanding of ABC gene evolution is important to the development of animal models and functional studies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping