ZFIN

ZFIN ID: ZDB-GENE-060303-1

ZFIN ID: ZDB-GENE-060303-1

CITATIONS (47 total)

Gene Name:	polymerase (DNA directed), gamma
Gene Symbol:	polg

Richard, J., Lizzo, G., Rochat, N., Jouary, A., Silva, P.T., Parisi, A., Christen, S., Moco, S., Orger, M.B., Gut, P. (2026) NAD+ and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutations. JCI insight. 11:

Brañas Casas, R., Zuppardo, A., Risato, G., Dinarello, A., Celeghin, R., Fontana, C., Grelloni, E., Gilea, A.I., Viscomi, C., Rasola, A., Dalla Valle, L., Lodi, T., Baruffini, E., Facchinello, N., Argenton, F., Tiso, N. (2024) Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment. Cell Death & Disease. 15:281281

Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576

Sabharwal, A., Wishman, M.D., Cervera, R.L., Serres, M.R., Anderson, J.L., Holmberg, S.R., Kar, B., Treichel, A.J., Ichino, N., Liu, W., Yang, J., Ding, Y., Deng, Y., Lacey, J.M., Laxen, W.J., Loken, P.R., Oglesbee, D., Farber, S.A., Clark, K.J., Xu, X., Ekker, S.C. (2022) Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. eLIFE. 11:

Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900

Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100

Lin, H., Lin, F., Yuan, J., Cui, F., Chen, J. (2021) Toxic effects and potential mechanisms of Fluxapyroxad to zebrafish (Danio rerio) embryos. The Science of the total environment. 769:144519

Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991

Giarmarco, M.M., Brock, D.C., Robbings, B.M., Cleghorn, W.M., Tsantilas, K.A., Kuch, K.C., Ge, W., Rutter, K.M., Parker, E.D., Hurley, J.B., Brockerhoff, S.E. (2020) Daily mitochondrial dynamics in cone photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 117:28816-28827

Gut, P., Matilainen, S., Meyer, J.G., Pällijeff, P., Richard, J., Carroll, C.J., Euro, L., Jackson, C.B., Isohanni, P., Minassian, B.A., Alkhater, R.A., Østergaard, E., Civiletto, G., Parisi, A., Thevenet, J., Rardin, M.J., He, W., Nishida, Y., Newman, J.C., Liu, X., Christen, S., Moco, S., Locasale, J.W., Schilling, B., Suomalainen, A., Verdin, E. (2020) SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nature communications. 11:5927

Kesh, S., Kannan, R.R., Balakrishnan, A. (2020) Naringenin alleviates 6-hydroxydopamine induced Parkinsonism in SHSY5Y cells and zebrafish model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108893

Kesh, S., Kannan, R.R., Sivaji, K., Balakrishnan, A. (2020) Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson's disease model. Neuroscience letters. 740:135426

Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031

Bian, W.P., Chen, Y., Luo, J., Wang, C., Xie, S., Pei, D. (2019) A knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system. ACS synthetic biology. 8(4):621-632

Park, K.H., Ye, Z.W., Zhang, J., Kim, S.H. (2019) Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish. Zebrafish. 16(6):497-504

Munro, B., Horvath, R., Müller, J.S. (2018) Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok-/- zebrafish. Human molecular genetics. 28(5):796-803

Sokol, A.M., Uszczynska-Ratajczak, B., Collins, M.M., Bazala, M., Topf, U., Lundegaard, P.R., Sugunan, S., Guenther, S., Kuenne, C., Graumann, J., Chan, S.S.L., Stainier, D.Y.R., Chacinska, A. (2018) Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish. PLoS Genetics. 14:e1007743

Zhou, W., Cao, L., Jeffries, J., Zhu, X., Staiger, C.J., Deng, Q. (2018) Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish. Disease models & mechanisms. 11(3)

Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z. (2017) Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)₂D₃.. Cell Reports. 19:1444-1455

Yang, Y., Liu, W., Li, D., Qian, L., Fu, B., Wang, C. (2017) Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 183:89-96

Babu, N.S., Murthy, C.L., Kakara, S., Sharma, R., Swamy, C.V., Idris, M.M. (2016) MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9):1407-20

Kumar, M.G., Rowley, S., Fulton, R., Dinday, M.T., Baraban, S.C., Patel, M. (2016) Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome. eNeuro. 3(2):e0008-16

Yang, Y., Liu, W., Mu, X., Qi, S., Fu, B., Wang, C. (2016) Biological response of zebrafish embryos after short-term exposure to thifluzamide. Scientific Reports. 6:38485

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Rahn, J.J., Bestman, J.E., Stackley, K.D., Chan, S.S. (2015) Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth. Nucleic acids research. 43(21):10338-52

Rahn, J.J., Stackley, K.D., and Chan, S.S. (2013) Opa1 is required for proper mitochondrial metabolism in early development. PLoS One. 8(3):e59218

Artuso, L., Romano, A., Verri, T., Domenichini, A., Argenton, F., Santorelli, F.M., and Petruzzella, V. (2012) Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio). Biochim. Biophys. Acta Bio-Energetics. 1817(7):1002-1011

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Additional Citations (19):

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2016) Nomenclature Data Curation (2016). Nomenclature Committee Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.