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ZIRC
ZFIN ID: ZDB-GENE-060303-1
Gene Name: polymerase (DNA directed), gamma
Gene Symbol: polg
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have 3'-5' exonuclease activity and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication. Predicted to localize to the mitochondrion. Used to  ...
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
muz119 Indel Unknown Premature Stop TALEN
muz120 Small Deletion Unknown Premature Stop TALEN
muz121 Small Deletion Unknown Unknown TALEN
sa9574 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44240 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH polg HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    mitochondrial DNA depletion syndrome 4a Mitochondrial DNA depletion syndrome 4A (Alpers type) 203700
    mitochondrial DNA depletion syndrome 4b Mitochondrial DNA depletion syndrome 4B (MNGIE type) 613662
    sensory ataxic neuropathy, dysarthria, and ophthalmoparesis Mitochondrial recessive ataxia syndrome (includes SANDO and SCAE) 607459
    Progressive external ophthalmoplegia, autosomal dominant 1 157640
    Progressive external ophthalmoplegia, autosomal recessive 1 258450
    DISEASE ASSOCIATED WITH polg VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    mitochondrial metabolism disease polgmuz120/muz120(AB) standard conditions Rahn et al., 2015
    polgmuz119/muz119(AB) standard conditions Rahn et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA replication (more)
    Cellular Component gamma DNA polymerase complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA polg-002 (1) 812
    mRNA polg-202 (1) 4875
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM polg No data available
    MARKER RELATIONSHIPS
    polgContained in: [BAC] CH211-198O8 (1) (order this), CH211-200N5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001921095 (1) 4257bp
    Genomic GenBank:CR854881 (1) 193195bp
    Select Tool
    Polypeptide UniProtKB:F8W5R6 (1) 1206aa
    Sequence Clusters UniGene:151371 (1)
    Sequence Information (all 9)
    ORTHOLOGY for polg (Chr: 25)
    CITATIONS (27)