ZFIN ID: ZDB-GENE-040312-3
CITATIONS (63 total)
Gene Name: cannabinoid receptor 1
Gene Symbol: cnr1
Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
Park, Y.M., Dahlem, C., Meyer, M.R., Kiemer, A.K., Müller, R., Herrmann, J. (2022) Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism. Molecules. 27(4):
Son, H.W., Ali, D.W. (2022) Endocannabinoid Receptor Expression in Early Zebrafish Development. Developmental neuroscience. 44(3):142-152
Knuth, M.M., Stutts, W.L., Ritter, M.M., Garrard, K.P., Kullman, S.W. (2021) Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Journal of Lipid Research. 62:100142
Li, Z., Jiang, B., Cao, B., Zhang, Z., Zhang, J., Li, J., Huang, Y., Wang, Y. (2021) Characterization of Four Orphan Receptors (GPR3, GPR6, GPR12 and GPR12L) in Chickens and Ducks and Regulation of GPR12 Expression in Ovarian Granulosa Cells by Progesterone. Genes. 12(4):
Orr, S.A., Ahn, S., Park, C., Miller, T.H., Kassai, M., Issa, F.A. (2021) Social Experience Regulates Endocannabinoids Modulation of Zebrafish Motor Behaviors. Frontiers in behavioral neuroscience. 15:668589
Forner-Piquer, I., Beato, S., Piscitelli, F., Santangeli, S., Di Marzo, V., Habibi, H.R., Maradonna, F., Carnevali, O. (2020) Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Environmental pollution (Barking, Essex : 1987). 264:114710
Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
Luchtenburg, F.J., Schaaf, M.J.M., Richardson, M.K. (2019) Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis. Psychopharmacology. 236(7):2049-2058
Zuccarini, G., D'Atri, I., Cottone, E., Mackie, K., Shainer, I., Gothilf, Y., Provero, P., Bovolin, P., Merlo, G.R. (2019) Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. International Journal of Molecular Sciences. 21(1):
Forner-Piquer, I., Santangeli, S., Maradonna, F., Rabbito, A., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2018) Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Environmental pollution (Barking, Essex : 1987). 241:1-8
Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125
Imperatore, R., D'Angelo, L., Safari, O., Motlagh, H.A., Piscitelli, F., de Girolamo, P., Cristino, L., Varricchio, E., di Marzo, V., Paolucci, M. (2018) Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish. Frontiers in Neuroanatomy. 12:62
Krug, R.G., Lee, H.B., El Khoury, L.Y., Sigafoos, A.N., Petersen, M.O., Clark, K.J. (2018) The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish. PLoS One. 13:e0190897
Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
Forner-Piquer, I., Maradonna, F., Gioacchini, G., Santangeli, S., Allarà, M., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2017) Dose - specific effects of Di-isononyl phthalate on the endocannabinoid system and on liver of female zebrafish. Endocrinology. 158(10):3462-3476
Gioacchini, G., Rossi, G., Carnevali, O. (2017) Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches. Scientific Reports. 7:1261
Chiarlone, A., Börner, C., Martín-Gómez, L., Jiménez-González, A., García-Concejo, A., García-Bermejo, M.L., Lorente, M., Blázquez, C., García-Taboada, E., de Haro, A., Martella, E., Höllt, V., Rodríguez, R., Galve-Roperh, I., Kraus, J., Guzmán, M. (2016) MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling. Neuropharmacology. 108:345-52
Falcinelli, S., Rodiles, A., Unniappan, S., Picchietti, S., Gioacchini, G., Merrifield, D.L., Carnevali, O. (2016) Probiotic treatment reduces appetite and glucose level in the zebrafish model. Scientific Reports. 6:18061
Liu, L.Y., Alexa, K., Cortes, M., Schatzman-Bone, S., Kim, A.J., Mukhopadhyay, B., Cinar, R., Kunos, G., North, T.E., Goessling, W. (2016) Cannabinoid receptor signaling regulates liver development and metabolism. Development (Cambridge, England). 143:609-22
Martella, A., Sepe, R.M., Silvestri, C., Zang, J., Fasano, G., Carnevali, O., De Girolamo, P., Neuhauss, S.C., Sordino, P., Di Marzo, V. (2016) Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(12):4275-4288
Martella, A., Silvestri, C., Maradonna, F., Gioacchini, G., Allarà, M., Radaelli, G., Overby, D.R., Di Marzo, V., Carnevali, O. (2016) Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop. Endocrinology. 157(5):1751-63
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
Fraher, D., Ellis, M.K., Morrison, S., McGee, S.L., Ward, A.C., Walder, K., Gibert, Y. (2015) Lipid abundance in zebrafish embryos is regulated by complementary actions of the Endocannabinoid System and Retinoic Acid Pathway. Endocrinology. 156(10):3596-609
Gorissen, M., Manuel, R., Pelgrim, T.N., Mes, W., de Wolf, M.J., Zethof, J., Flik, G., van den Bos, R. (2015) Differences in inhibitory avoidance, cortisol and brain gene expression in TL and AB zebrafish. Genes, brain, and behavior. 14(5):428-38
Manuel, R., Gorissen, M., Stokkermans, M., Zethof, J., Ebbesson, L.O., Vis, H.V., Flik, G., Bos, R.V. (2015) The Effects of Environmental Enrichment and Age-Related Differences on Inhibitory Avoidance in Zebrafish (Danio rerio Hamilton). Zebrafish. 12(2):152-65
Manuel, R., Zethof, J., Flik, G., Bos, R.V. (2015) Providing a food reward reduces inhibitory avoidance learning in zebrafish. Behavioural processes. 120:69-72
Manuel, R., Gorissen, M., Zethof, J., Ebbesson, L.O., van de Vis, H., Flik, G., van den Bos, R. (2014) Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase. The Journal of experimental biology. 217(Pt 21):3919-28
Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
Aoki, T., Kinoshita, M., Aoki, R., Agetsuma, M., Aizawa, H., Yamazaki, M., Takahoko, M., Amo, R., Arata, A., Higashijima, S.I., Tsuboi, T., and Okamoto, H. (2013) Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program. Neuron. 78(5):881-894
Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
Harvey-Girard, E., Giassi, A.C., Ellis, W., and Maler, L. (2013) Expression of the cannabinoid CB1 receptor in the gymnotiform fish brain and its implications for the organization of the teleost pallium. The Journal of comparative neurology. 521(4):949-975
Liu, Y.J., Fan, H.B., Jin, Y., Ren, C.G., Jia, X.E., Wang, L., Chen, Y., Dong, M., Zhu, K.Y., Dong, Z.W., Ye, B.X., Zhong, Z., Deng, M., Liu, T.X., and Ren, R. (2013) Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway. The Journal of biological chemistry. 288(19):13551-62
Pai, W.Y., Hsu, C.C., Lai, C.Y., Chang, T.Z., Tsai, Y.L., and Her, G.M. (2013) Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity through the induction of SREBP-1c expression in zebrafish. Transgenic Research. 22(4):823-38
Klee, E.W., Schneider, H., Clark, K.J., Cousin, M.A., Ebbert, J.O., Hooten, W.M., Karpyak, V.M., Warner, D.O., and Ekker, S.C. (2012) Zebrafish: a model for the study of addiction genetics. Human genetics. 131(6):977-1008
Nishio, S.I., Gibert, Y., Berekelya, L., Bernard, L., Brunet, F., Guillot, E., Le Bail, J.C., Sánchez, J.A., Galzin, A.M., Triqueneaux, G., and Laudet, V. (2012) Fasting Induces CART Down-Regulation in the Zebrafish Nervous System in a Cannabinoid Receptor 1-Dependent Manner. Molecular endocrinology (Baltimore, Md.). 26(8):1316-1326
Shimada, Y., Hirano, M., Nishimura, Y., and Tanaka, T. (2012) A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS One. 7(12):e52549
Piccinetti, C.C., Migliarini, B., Olivotto, I., Coletti, G., Amici, A., and Carnevali, O. (2010) Appetite regulation: The central role of melatonin in Danio rerio. Hormones and behavior. 58(5):780-785
Migliarini, B., and Carnevali, O. (2009) A novel role for the endocannabinoid system during zebrafish development. Molecular and Cellular Endocrinology. 299(2):172-177
Migliarini, B., and Carnevali, O. (2008) Anandamide modulates growth and lipid metabolism in the zebrafish Danio rerio. Molecular and Cellular Endocrinology. 286(1-2):S1:S12-S16
Watson, S., Chambers, D., Hobbs, C., Doherty, P., and Graham, A. (2008) The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation. Molecular and cellular neurosciences. 38(1):89-97
McPartland, J.M., Glass, M., Matias, I., Norris, R.W., and Kilpatrick, C.W. (2007) A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). Molecular genetics and genomics : MGG. 277(5):555-570
Lam, C.S., Rastegar, S., and Strähle, U. (2006) Distribution of cannabinoid receptor 1 in the CNS of zebrafish. Neuroscience. 138(1):83-95
Additional Citations (19):
ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.
Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
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