ZFIN

ZFIN ID: ZDB-GENE-031217-1

ZFIN ID: ZDB-GENE-031217-1

CITATIONS (70 total)

Gene Name:	low density lipoprotein receptor a
Gene Symbol:	ldlra

Li, H.Y., Zeng, W.L., Ye, Y.W., Chen, X., Zhang, M.M., Chen, Y.S., Liu, C.T., Zhong, Z.Q., Li, J., Wang, Y. (2025) Glia maturation factor-β in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish. American journal of physiology. Gastrointestinal and liver physiology. :

Sweeney, D.W., Shen, M.C., Farber, S.A. (2025) Creb3l3 deficiency promotes intestinal lipid accumulation and alters ApoB-containing lipoprotein kinetics. Journal of Lipid Research. :100833100833

Gence, L., Morello, E., Rastegar, S., Apalama, M.L., Meilhac, O., Bascands, J.L., Diotel, N. (2024) Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis. The European journal of neuroscience. 61(1):e16586

Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908

Liu, Z., Zhang, N., Wang, C., Shi, L., Hu, Y., Wang, Y., Li, J. (2024) Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish†. Biology of reproduction. 111(1):123-134

Yinger, R.V., Evangelisto, C.J., Tucker, N.C., Billingsley, J.M., Clair, S.L.S. (2024) β-Estradiol Supplementation Regulates Cholesterol Synthesis Independent of Unsaturated Fat Consumption in Adult Zebrafish. Zebrafish. 21:223230223-230

Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):

Guirgis, F.W., Jacob, V., Wu, D., Henson, M., Daly-Crews, K., Hopson, C., Black, L.P., DeVos, E.L., Sulaiman, D., Labilloy, G., Brusko, T.M., Shavit, J.A., Bertrand, A., Feldhammer, M., Baskovich, B., Graim, K., Datta, S., Reddy, S.T. (2023) DHCR7 Expression Predicts Porsusor Outcomes and Mortality From Sepsis. Critical care explorations. 5:e0929e0929

Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):

Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350

Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020

Williams, M.B., Green, G.B., Palmer, J.W., Fay, C.X., Chehade, S.B., Lawrence, A.L., Barry, R.J., Powell, M.L., Harris, M.L., Watts, S.A. (2023) Replacement of Dietary Fish Protein with Bacterial Protein Results in Decreased Adiposity Coupled with Liver Gene Expression Changes in Female Danio rerio. Current developments in nutrition. 8:102057102057

Zhang, L., Tong, Y., Fang, Y., Pei, J., Wang, Q., Li, G. (2023) Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment. Lipids in health and disease. 22:203203

Gora, A.H., Rehman, S., Kiron, V., Dias, J., Fernandes, J.M.O., Olsvik, P.A., Siriyappagouder, P., Vatsos, I., Schmid-Staiger, U., Frick, K., Cardoso, M. (2022) Management of Hypercholesterolemia Through Dietary ß-glucans-Insights From a Zebrafish Model. Frontiers in nutrition. 8:797452

Hu, Y.X., You, H.M., Zhu, R.F., Liang, Y.L., Li, F.F., Qin, Y.W., Zhao, X.X., Liang, C., Jing, Q. (2022) Establishment of a lipid metabolism disorder model in ApoEb mutant zebrafish. Atherosclerosis. 361:18-29

Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U., den Hoed, M., Ameur, A. (2022) CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature communications. 13:627

Verwilligen, R.A.F., Mulder, L., Rodenburg, F.J., Van Dijke, A., Hoekstra, M., Bussmann, J., Van Eck, M. (2022) Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Atherosclerosis. 346:18-25

White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:

Kong, Y., Li, Y., Dai, Z.R., Qin, M., Fan, H.L., Hao, J.G., Zhang, C.X., Zhong, Q.P., Qi, C., Wang, P. (2021) Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high-cholesterol diet-fed zebrafish. Food science & nutrition. 9:5198-5210

Sun, S.X., Wu, J.L., Lv, H.B., Zhang, H.Y., Zhang, J., Limbu, S.M., Qiao, F., Chen, L.Q., Yang, Y., Zhang, M.L., Du, Z.Y. (2020) Environmental estrogen exposure converts lipid metabolism in male fish to a female pattern mediated by AMPK and mTOR signaling pathways. Journal of hazardous materials. 394:122537

Zhao, Y., Cao, X., Fu, L., Gao, J. (2020) n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterol homeostasis in fish. Applied Microbiology and Biotechnology. 104(5):2149-2161

Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139

Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J.D., Wang, R., Xiong, F., Meng, S., Clements, T.P., Tandon, B., Wagner, D.S., Diaz, M.F., Wenzel, P.L., Miller, Y.I., Traver, D., Cooke, J.P., Li, W., Zon, L.I., Chen, K., Bai, Y., Fang, L. (2019) AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science (New York, N.Y.). 363:1085-1088

Kaur, N., Chugh, H., Tomar, V., Sakharkar, M.K., Dass, S.K., Chandra, R. (2019) Cinnamon attenuates adiposity and affects the expression of metabolic genes in Diet-Induced obesity model of zebrafish. Artificial cells, nanomedicine, and biotechnology. 47:2930-2939

Park, K.H., Kim, S.H. (2019) Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 117:109179

Park, K.H., Ye, Z.W., Zhang, J., Kim, S.H. (2019) Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish. Zebrafish. 16(6):497-504

Han, B., Kou, S., He, K., Han, Y., Wang, Y., Huang, T., Zhou, X., Xiao, Y., Li, X., Ye, X. (2018) Anti-hypercholesterolemic Effect of Berbamine Isolated from Rhizoma Coptidis in Hypercholesterolemic Zebrafish Induced by High-Cholesterol Diet.. Iranian journal of pharmaceutical research : IJPR. 17:292-306

Johansen, M.D., Hortle, E., Kasparian, J.A., Romero, A., Novoa, B., Figueras, A., Britton, W.J., de Silva, K., Purdie, A.C., Oehlers, S.H. (2018) Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & shellfish immunology. 83:238-242

Montasser, M.E., O'Hare, E.A., Wang, X., Howard, A.D., McFarland, R., Perry, J.A., Ryan, K.A., Rice, K., Jaquish, C.E., Shuldiner, A.R., Miller, M., Mitchell, B.D., Zaghloul, N.A., Chang, Y.C. (2018) An APOO Pseudogene on Chromosome 5q is Associated with LDL-C Levels. Circulation. 138(13):1343-1355

Pradhan, A., Olsson, P.E. (2018) Germ cell depletion in zebrafish leads to incomplete masculinization of the brain. General and comparative endocrinology. 265:15-21

Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69

Liu, C., Kim, Y.S., Kim, J., Pattison, J., Kamaid, A., Miller, Y.I. (2017) Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish. Journal of Lipid Research. 59(2):391-399

Al-Habsi, A.A., Massarsky, A., Moon, T.W. (2016) Exposure to gemfibrozil and atorvastatin affects cholesterol metabolism and steroid production in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 199:87-96

Zhang, J., Sun, P., Kong, T., Yang, F., Guan, W. (2016) Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquatic toxicology (Amsterdam, Netherlands). 170:208-215

Chatzopoulou, A., Roy, U., Meijer, A.H., Alia, A., Spaink, H.P., Schaaf, M.J. (2015) Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish. Endocrinology. 156(5):1757-69

Dai, Z., Wang, H., Jin, X., Wang, H., He, J., Liu, M., Yin, Z., Sun, Y., Lou, Q. (2015) Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. American journal of physiology. Endocrinology and metabolism. 308(10):E849-59

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Jia, X.E., Ma, K., Xu, T., Gao, L., Wu, S., Fu, C., Zhang, W., Wang, Z., Liu, K., Dong, M., Jing, C., Ren, C., Dong, Z., Chen, Y., Jin, Y., Huang, Q., Chang, X., Deng, M., Li, L., Luo, L., Zhu, J., Dang, Y., Chang, H.C., Zon, L.I., Zhou, Y., Chen, S., Pan, W. (2015) Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Research. 25(8):946-62

O'Hare, E.A., Wang, X., Montasser, M.E., Chang, Y.P., Mitchell, B.D., Zaghloul, N.A. (2014) Disruption of ldlr causes increased LDL-cholesterol and vascular lipid accumulation in a zebrafish model of hypercholesterolemia. Journal of Lipid Research. 55(11):2242-53

Yu, C., Zhang, Y., Yao, S., Wei, Y. (2014) A PCR Based Protocol for Detecting Indel Mutations Induced by TALENs and CRISPR/Cas9 in Zebrafish. PLoS One. 9:e98282

Her, G.M., Pai, W.Y., Lai, C.Y., Hsieh, Y.W., and Pang, H.W. (2013) Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1831(6):1037-51

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Levi, L., Ziv, T., Admon, A., Levavi-Sivan, B., and Lubzens, E. (2012) Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish. American journal of physiology. Endocrinology and metabolism. 302(6):E626-644

Her, G.M., Hsu, C.C., Hong, J.R., Lai, C.Y., Hsu, M.C., Pang, H.W., Chan, S.K., and Pai, W.Y. (2011) Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio). Biochimica et biophysica acta. Molecular and cell biology of lipids. 1811(9):536-48

Tainaka, T., Shimada, Y., Kuroyanagi, J., Zang, L., Oka, T., Nishimura, Y., Nishimura, N., and Tanaka, T. (2011) Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutrition & metabolism. 8(1):88

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Gregg, R.G., Willer, G.B., Fadool, J.M., Dowling, J.E., and Link, B.A. (2003) Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 100(11):6535-6540

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Additional Citations (22):

Zebrafish Nomenclature Committee (2026) Nomenclature Data Curation (2026). Nomenclature Committee Submission.

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2019) Analysis of data directly submitted to the Zebrafish International Resource Center (ZIRC). ZFIN Direct Data Submission.

Zebrafish Nomenclature Committee (2017) Nomenclature Data Curation (2017). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.