PUBLICATION
β-Estradiol Supplementation Regulates Cholesterol Synthesis Independent of Unsaturated Fat Consumption in Adult Zebrafish
- Authors
- Yinger, R.V., Evangelisto, C.J., Tucker, N.C., Billingsley, J.M., Clair, S.L.S.
- ID
- ZDB-PUB-240416-1
- Date
- 2024
- Source
- Zebrafish 21: 223230223-230 (Journal)
- Registered Authors
- Keywords
- Hmgcr, cholesterol, estradiol, estrogen, obesity, zebrafish
- MeSH Terms
-
- Estrogens/metabolism
- Female
- Cholesterol/metabolism
- Fats, Unsaturated*/metabolism
- Animals
- Male
- Zebrafish*/metabolism
- Obesity/etiology
- Dietary Supplements
- Estradiol/metabolism
- Estradiol/pharmacology
- PubMed
- 38621217 Full text @ Zebrafish
Citation
Yinger, R.V., Evangelisto, C.J., Tucker, N.C., Billingsley, J.M., Clair, S.L.S. (2024) β-Estradiol Supplementation Regulates Cholesterol Synthesis Independent of Unsaturated Fat Consumption in Adult Zebrafish. Zebrafish. 21:223230223-230.
Abstract
Obesity is a public health concern resulting in a variety of health complications, including heart disease and insulin resistance. Estrogens have been associated with a reduced risk of obesity, but this relationship remains incompletely understood. We assessed the role of 17β-estradiol (E2) in mitigating complications associated with obesity by supplementing E2 in the diets of overfed zebrafish. We report that dietary E2 supplementation protects against weight gain and modulates de novo cholesterol synthesis in a sex-specific manner. Our studies lead us to propose a model in which E2 regulates hmgcr expression independently of unsaturated fat consumption. These data can be used to develop sex-specific treatments for obesity-related health conditions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping