PUBLICATION

β-Estradiol Supplementation Regulates Cholesterol Synthesis Independent of Unsaturated Fat Consumption in Adult Zebrafish

Authors
Yinger, R.V., Evangelisto, C.J., Tucker, N.C., Billingsley, J.M., Clair, S.L.S.
ID
ZDB-PUB-240416-1
Date
2024
Source
Zebrafish   21: 223230223-230 (Journal)
Registered Authors
Keywords
Hmgcr, cholesterol, estradiol, estrogen, obesity, zebrafish
MeSH Terms
  • Female
  • Zebrafish*/metabolism
  • Fats, Unsaturated*/metabolism
  • Cholesterol/metabolism
  • Obesity/etiology
  • Animals
  • Estradiol/metabolism
  • Estradiol/pharmacology
  • Male
  • Estrogens/metabolism
  • Dietary Supplements
(all 11)
PubMed
38621217 Full text @ Zebrafish
Abstract
Obesity is a public health concern resulting in a variety of health complications, including heart disease and insulin resistance. Estrogens have been associated with a reduced risk of obesity, but this relationship remains incompletely understood. We assessed the role of 17β-estradiol (E2) in mitigating complications associated with obesity by supplementing E2 in the diets of overfed zebrafish. We report that dietary E2 supplementation protects against weight gain and modulates de novo cholesterol synthesis in a sex-specific manner. Our studies lead us to propose a model in which E2 regulates hmgcr expression independently of unsaturated fat consumption. These data can be used to develop sex-specific treatments for obesity-related health conditions.
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