ZFIN

ZFIN ID: ZDB-GENE-030903-3

ZFIN ID: ZDB-GENE-030903-3

CITATIONS (88 total)

Gene Name:	nuclear receptor subfamily 1, group I, member 2
Gene Symbol:	nr1i2

Erradhouani, C., Geffroy, F., Piccini, B., Hinfray, N., Chadili, E., Balaguer, P., Sohm, F., Aït-Aïssa, S., Coumoul, X., Brion, F. (2025) A new alternative method using cyp3a65 expression in transgenic zebrafish embryos to assess metabolic endocrine-disrupting chemicals in the intestine. Environment International. 205:109872

Erradhouani, C., Piccini, B., Maillot-Marechal, E., Aït-Aïssa, S., Balaguer, P., Coumoul, X., Brion, F. (2025) New insights into the regulation of cyp3a65 expression in transgenic tg(cyp3a65:GFP) zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 279:107250

Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):

Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417

Chen, S., Lathrop, K.L., Kuwajima, T., Gross, J.M. (2021) Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retina. Development (Cambridge, England). 149(8):

Creusot, N., Garoche, C., Grimaldi, M., Boulahtouf, A., Chiavarina, B., Bourguet, W., Balaguer, P. (2021) A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays. Frontiers in endocrinology. 12:665521

Leach, L.L., Hanovice, N.J., George, S.M., Gabriel, A.E., Gross, J.M. (2021) The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration. Proceedings of the National Academy of Sciences of the United States of America. 118(21)

Wang, Y., Shen, D., Ullah, N., Diaby, M., Gao, B., Song, C. (2021) Characterization and expression pattern of ZB and PS transposons in zebrafish. Gene expression patterns : GEP. 42:119203

Creusot, N., Gassiot, M., Alaterre, E., Chiavarina, B., Grimaldi, M., Boulahtouf, A., Toporova, L., Gerbal-Chaloin, S., Daujat-Chavanieu, M., Matheux, A., Rahmani, R., Gongora, C., Evrard, A., Pourquier, P., Balaguer, P. (2020) The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor. Cells. 9(7):

Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622

Ma, Y.N., Sun, L.H., Li, S.Y., Ni, Y.X., Cao, Z.Y., Chen, M.X., Mou, R.X. (2020) Modulation of steroid metabolism and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to triadimefon. Environmental pollution (Barking, Essex : 1987). 262:114145

Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171

Faltermann, S., Hettich, T., Küng, N., Fent, K. (2019) Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 218:105372

Hamid, N., Junaid, M., Pei, D.S. (2019) Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China. Journal of hazardous materials. 382:121106

Hu, J., Tian, J., Zhang, F., Wang, H., Yin, J. (2019) Pxr- and Nrf2- mediated induction of ABC transporters by heavy metal ions in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 255:113329

Ji, K., Seo, J., Kho, Y., Choi, K. (2019) Co-exposure to ketoconazole alters effects of bisphenol A in Danio rerio and H295R cells. Chemosphere. 237:124414

Junaid, M., Wang, Y., Hamid, N., Deng, S., Li, W.G., Pei, D.S. (2019) Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach. Journal of hazardous materials. 380:120828

Salanga, M.C., Brun, N.R., Francolini, R.D., Stegeman, J.J., Goldstone, J.V. (2019) CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cyp3a65 in zebrafish (Danio rerio) larvae. Toxicological sciences : an official journal of the Society of Toxicology. 174(1):51-62

Willi, R.A., Salgueiro-González, N., Faltermann, S., Hettich, T., Fent, K. (2019) Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. The Science of the total environment. 672:183-191

He, Y., Sun, C., Zhang, Y., Folkerts, E.J., Martin, J.W., Goss, G.G. (2018) Developmental Toxicity of the Organic Fraction from Hydraulic Fracturing Flowback and Produced Waters to Early Life Stages of Zebrafish (Danio rerio). Environmental science & technology. 52(6):3820-3830

Laizé, V., Gavaia, P.J., Tarasco, M., Viegas, M.N., Caria, J., Luis, N., Cancela, M.L. (2018) Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and environmental safety. 161:721-728

Lille-Langøy, R., Karlsen, O.A., Myklebust, L.M., Goldstone, J.V., Mork-Jansson, A., Male, R., Blumberg, B., Stegeman, J.J., Goksøyr, A. (2018) Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicological sciences : an official journal of the Society of Toxicology. 168(1):28-39

Liu, Y., Junaid, M., Wang, Y., Tang, Y.M., Bian, W.P., Xiong, W.X., Huang, H.Y., Chen, C.D., Pei, D.S. (2018) New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach. Aquatic toxicology (Amsterdam, Netherlands). 201:151-161

Mishra, S., Wu, S.Y., Fuller, A.W., Wang, Z., Rose, K.L., Schey, K.L., Mchaourab, H.S. (2018) Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. The Journal of biological chemistry. 293(2):740-753

Tian, J., Hu, J., Liu, G., Yin, H., Chen, M., Miao, P., Bai, P., Yin, J. (2018) Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots. Environmental pollution (Barking, Essex : 1987). 244:588-599

Blanco, M., Pérez-Albaladejo, E., Piña, B., Kušpilić, G., Milun, V., Lille-Langøy, R., Karlsen, O.A., Goksøyr, A., Porte, C. (2017) Assessing the environmental quality of sediments from Split coastal area (Croatia) with a battery of cell-based bioassays. The Science of the total environment. 624:1640-1648

Huang, S.S., Benskin, J.P., Veldhoen, N., Chandramouli, B., Butler, H., Helbing, C.C., Cosgrove, J.R. (2017) A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae. Aquatic toxicology (Amsterdam, Netherlands). 182:102-112

Jackson, J.S., Kennedy, C.J. (2017) Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 200:34-41

Kim, K., Jeon, H.J., Choi, S.D., Tsang, D.C.W., Oleszczuk, P., Ok, Y.S., Lee, H.S., Lee, S.E. (2017) Combined toxicity of endosulfan and phenanthrene mixtures and induced molecular changes in adult Zebrafish (Danio rerio). Chemosphere. 194:30-41

Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44

Willi, R.A., Faltermann, S., Hettich, T., Fent, K. (2017) Active glucocorticoids have a range of important adverse developmental and physiological effects on developing zebrafish embryos. Environmental science & technology. 52(2):877-885

Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130

Zhang, L., Jin, Y., Han, Z., Liu, H., Shi, L., Hua, X., A Doering, J., Tang, S., P Giesy, J., Yu, H. (2017) INTEGRATED IN SILICO AND IN VIVO APPROACHES TO INVESTIGATE EFFECTS OF BDE-99 MEDIATED BY THE NUCLEAR RECEPTORS ON DEVELOPING ZEBRAFISH. Environmental toxicology and chemistry. 37(3):780-787

Zhang, Q., Zhang, Y., Du, J., Zhao, M. (2017) Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo. Chemosphere. 185:1173-1180

Chen, Q., Jia, A., Snyder, S.A., Gong, Z., Lam, S.H. (2016) Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 144:1162-1169

Cheng, J., Lv, S., Nie, S., Liu, J., Tong, S., Kang, N., Xiao, Y., Dong, Q., Huang, C., Yang, D. (2016) Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 176:45-52

Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2016) Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquatic toxicology (Amsterdam, Netherlands). 178:182-189

Jeon, H.J., Lee, Y.H., Kim, M.J., Choi, S.D., Park, B.J., Lee, S.E. (2016) Integrated biomarkers induced by chlorpyrifos in two different life stages of zebrafish (Danio rerio) for environmental risk assessment. Environmental Toxicology and Pharmacology. 43:166-174

Pérez-Albaladejo, E., Rizzi, J., Fernandes, D., Lille-Langøy, R., Karlsen, O.A., Goksøyr, A., Oros, A., Spagnoli, F., Porte, C. (2016) Assessment of the environmental quality of coastal sediments by using a combination of in vitro bioassays. Marine pollution bulletin. 108(1-2):53-61

Zhao, Y., Zhang, K., Fent, K. (2016) Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Environmental science & technology. 50(18):10245-54

Cheng, Y.Y., Tao, W.J., Chen, J.L., Sun, L.N., Zhou, L.Y., Song, Q., Wang, D.S. (2015) Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Gene. 569(1):141-52

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Fernández, I., Vijayakumar, P., Marques, C., Cancela, M.L., Gavaia, P.J., Laizé, V. (2015) Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish physiology and biochemistry. 41(3):745-59

Kubota, A., Goldstone, J.V., Lemaire, B., Takata, M., Woodin, B.R., Stegeman, J.J. (2015) Pregnane X Receptor and Aryl Hydrocarbon Receptor Both Are Involved in Transcriptional Regulation of pxr, CYP2 and CYP3 Genes in Developing Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 143(2):398-407

Liu, H., Tang, S., Zheng, X., Zhu, Y., Ma, Z., Liu, C., Hecker, M., Saunders, D.M., Giesy, J.P., Zhang, X., Yu, H. (2015) Bioaccumulation, biotransformation and toxicity of BDE-47, 6-OH-BDE-47 and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio). Environmental science & technology. 49(3):1823-33

Ma, Z., Yu, Y., Tang, S., Liu, H., Su, G., Xie, Y., Giesy, J.P., Hecker, M., Yu, H. (2015) Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 169:196-203

Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554

Blüthgen, N., Meili, N., Chew, G., Odermatt, A., and Fent, K. (2014) Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). The Science of the total environment. 476-477:207-217

Fernández, I., Santos, A., Cancela, M.L., Laizé, V., Gavaia, P.J. (2014) Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins. Environmental pollution (Barking, Essex : 1987). 194C:86-95

Bainy, A.C., Kubota, A., Goldstone, J.V., Lille-Langøy, R., Karchner, S.I., Celander, M.C., Hahn, M.E., Goksøyr, A., and Stegeman, J.J. (2013) Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 142-143:447-457

Chang, C.T., Chung, H.Y., Su, H.T., Tseng, H.P., Tzou, W.S., and Hu, C.H. (2013) Regulation of zebrafish CYP3A65 transcription by AHR2. Toxicology and applied pharmacology. 270(2):174-184

Kubota, A., Bainy, A.C., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2013) The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology. 272(1):172-9

Li, X., Ma, J., Fang, Q., and Li, Y. (2013) Transcription alterations of microRNAs, cytochrome P4501A and 3A, and AhR and PXR in the liver of zebrafish exposed to crude microcystins. Toxicon : official journal of the International Society on Toxinology. 73:17-22

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Fidler, A.E., Holland, P.T., Reschly, E.J., Ekins, S., and Krasowski, M.D. (2012) Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants. Toxicon : official journal of the International Society on Toxinology. 59(2):365-372

Krasowski, M.D., Ai, N., Hagey, L.R., Kollitz, E.M., Kullman, S.W., Reschly, E.J., and Ekins, S. (2011) The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. BMC biochemistry. 12:5

Lister, A., Regan, C., Van Zwol, J., and Van Der Kraak, G. (2009) Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: A mechanistic evaluation. Aquatic toxicology (Amsterdam, Netherlands). 95(4):320-329

Ekins, S., Reschly, E.J., Hagey, L.R., and Krasowski, M.D. (2008) Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evolutionary Biology. 8(1):103

Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188

Reschly, E.J., Bainy, A.C., Mattos, J.J., Hagey, L.R., Bahary, N., Mada, S.R., Ou, J., Venkataramanan, R., and Krasowski, M.D. (2007) Functional evolution of the vitamin D and pregnane X receptors. BMC Evolutionary Biology. 7:222

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Bresolin, T., de Freitas Rebelo, M., Celso Dias Bainy, A. (2005) Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 140(3-4):403-407

Krasowski, M.D., Yasuda, K., Hagey, L.R., and Schuetz, E.G. (2005) Evolution of the pregnane X receptor: adaptation to cross-species differences in biliary bile salts. Molecular endocrinology (Baltimore, Md.). 19(7):1720-1739

Krasowski, M.D., Yasuda, K., Hagey, L.R., and Schuetz, E.G. (2005) Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nuclear Receptor. 3(1):2

Bainy, A.C.D. and Stegeman, J.J. (2004) Abstracts from the Twelfth International Symposium on Pollutant Responses in Marine Organisms (PRIMO 12) Receptors and Regulation of Cytochrome P450 - Cloning and identification of a full length pregnane X receptor and expression in vivo in zebrafish (Danio rerio). Marine Environmental Research. 58:133-134

Moore, L.B., Maglich, J.M., McKee, D.D., Wisely, B., Willson, T.M. Kliewer, S.A., Lambert, M.H., and Moore, J.T. (2002) Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Molecular endocrinology (Baltimore, Md.). 16(5):977-986

Additional Citations (22):

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M.S., Lewis, S.E., Thomas, P.D. (2010) Annotation inferences using phylogenetic trees. Automated Data Submission. 12:449-62

Thisse, C., and Thisse, B. (2008) Expression from: Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. ZFIN Direct Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.