ZFIN

ZFIN ID: ZDB-GENE-030901-2

ZFIN ID: ZDB-GENE-030901-2

CITATIONS (55 total)

Gene Name:	matrix metallopeptidase 14b (membrane-inserted)
Gene Symbol:	mmp14b

Kamei, C.N., Sampson, W.G.B., Albertz, C., Aries, O., Wolf, A., Upadhyay, R.M., Hughes, S.M., Schenk, H., Bonnet, F., Draper, B.B.W., McCracken, K.W., Marciano, D.K., Oxburgh, L., Drummond, I.A. (2026) Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney. Development (Cambridge, England). 153:dev205074

Kayman Kürekçi, G., Kaur Bajwa, G., Zhang, S., Leclerc, S., de Chantal, E., Belke, D., Andelfinger, G., Deniset, J.F., Marín-Juez, R. (2026) Attenuation of epicardial activation and myofibroblast abundance via the Fbln2-Nupr1b axis stimulates cardiac regeneration in zebrafish. Nature cardiovascular research. 5:218-233

Zhao, Y., Mei, X., Yang, J., Wang, Z., Liu, Q., Zhang, Y., Yang, D. (2025) β-Glucan pretreatment activates lectin pathway to maintain the function of intestinal Th17 cells for infectious enteritis protection. Zoological research. 46:141114241411-1424

Dennhag, N., Kahsay, A., Nissen, I., Nord, H., Chermenina, M., Liu, J., Arner, A., Liu, J.X., Backman, L.J., Remeseiro, S., von Hofsten, J., Pedrosa Domellöf, F. (2024) fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Nature communications. 15:1950

Gentile, A., Albu, M., Xu, Y., Mortazavi, N., Ribeiro da Silva, A., Stainier, D.Y.R., Gunawan, F. (2024) Mechanical forces remodel the cardiac extracellular matrix during zebrafish development. Development (Cambridge, England). 151(13):

Wei, M., Yu, Q., Li, E., Zhao, Y., Sun, C., Li, H., Liu, Z., Ji, G. (2024) Ace Deficiency Induces Intestinal Inflammation in Zebrafish. International Journal of Molecular Sciences. 25(11):

Zlatanova, I., Sun, F., Wu, R.S., Chen, X., Lau, B.H., Colombier, P., Sinha, T., Celona, B., Xu, S.M., Materna, S.C., Huang, G.N., Black, B.L. (2023) An injury-responsive mmp14b enhancer is required for heart regeneration. Science advances. 9:eadh5313

Rolland, L., Harrington, A., Faucherre, A., Abaroa, J.M., Gangatharan, G., Gamba, L., Severac, D., Pratlong, M., Moore-Morris, T., Jopling, C. (2022) The regenerative response of cardiac interstitial cells. Journal of molecular cell biology. 14(10):

Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595

Weaver, M.L., Piedade, W.P., Meshram, N.N., Famulski, J.K. (2020) Hyaloid vasculature and mmp2 activity play a role during optic fissure fusion in zebrafish. Scientific Reports. 10:10136

Johnston, E.F., Cadonic, I.G., Craig, P.M., Gillis, T.E. (2019) microRNA-29b knocks down collagen type I production in cultured rainbow trout (Oncorhynchus mykiss) cardiac fibroblasts. The Journal of experimental biology. 222(Pt 17):

Lu, J.K., Tsai, T.C., Lee, H., Hsia, K., Lin, C.H., Lu, J.H. (2019) Pectoral Fin Anomalies in tbx5a Knockdown Zebrafish Embryos Related to the Cascade Effect of N-Cadherin and Extracellular Matrix Formation. Journal of developmental biology. 7(3)

de Vos, I.J.H.M., Tao, E.Y., Ong, S.L.M., Goggi, J.L., Scerri, T., Wilson, G.R., Low, C.G.M., Wong, A.S.W., Grussu, D., Stegmann, A.P.A., van Geel, M., Janssen, R., Amor, D.J., Bahlo, M., Dunn, N.R., Carney, T.J., Lockhart, P.J., Coull, B.J., van Steensel, M.A.M. (2018) Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype. Human molecular genetics. 27(16):2775-2788

Enya, S., Kawakami, K., Suzuki, Y., Kawaoka, S. (2018) A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host.. Disease models & mechanisms. 11(8)

Hu, B., Gao, Y., Davies, L., Woo, S., Topczewski, J., Jessen, J.R., Lin, F. (2018) Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development (Cambridge, England). 145(17):

Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T., Becker, C.G. (2018) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nature communications. 9:4670

Gamba, L., Amin-Javaheri, A., Kim, J., Warburton, D., Lien, C.L. (2017) Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury. Journal of cardiovascular development and disease. 4(1)

Yang, R., Zhang, Y., Huang, D., Luo, X., Zhang, L., Zhu, X., Zhang, X., Liu, Z., Han, J., Xiong, J.W. (2017) Miconazole protects blood vessels from matrix metalloproteinase 9-dependent rupture and hemorrhage. Disease models & mechanisms. 10(3):337-348

Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. 296:31-41

Chu, L., Li, J., Liu, Y., Hu, W., Cheng, C.H. (2014) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular endocrinology (Baltimore, Md.). 28(11):1785-95

Dohn, M.R., Mundell, N.A., Sawyer, L.M., Dunlap, J.A., and Jessen, J.R. (2013) Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Developmental Biology. 383(1):39-51

Janssens, E., Gaublomme, D., De Groef, L., Darras, V.M., Arckens, L., Delorme, N., Claes, F., Van Hove, I., and Moons, L. (2013) Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development. PLoS One. 8(1):e52915

Williams, B.B., Cantrell, V.A., Mundell, N.A., Bennett, A.C., Quick, R.E., and Jessen, J.R. (2012) VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. Journal of Cell Science. 125(9):2141-2147

Jung, I.H., Jung, D.E., Park, Y.N., Song, S.Y., and Park, S.W. (2011) Aberrant hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PLoS One. 6(12):e27941

McGrail, M., Hatler, J.M., Kuang, X., Liao, H.K., Nannapaneni, K., Noack Watt, K.E., Uhl, J.D., Largaespada, D.A., Vollbrecht, E., Scheetz, T.E., Dupuy, A.J., Hostetter, J.M., and Essner, J.J. (2011) Somatic mutagenesis with a sleeping beauty transposon system leads to solid tumor formation in zebrafish. PLoS One. 6(4):e18826

Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21

Golubkov, V.S., Chekanov, A.V., Cieplak, P., Aleshin, A.E., Chernov, A.V., Zhu, W., Radichev, I.A., Zhang, D., Dong, P.D., and Strongin, A.Y. (2010) The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): implications in cancer and embryogenesis. The Journal of biological chemistry. 285(46):35740-35749

Yin, C., Kikuchi, K., Hochgreb, T., Poss, K.D., and Stainier, D.Y. (2010) Hand2 Regulates Extracellular Matrix Remodeling Essential for Gut-Looping Morphogenesis in Zebrafish. Developmental Cell. 18(6):973-984

Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418

Wyatt, R.A., Keow, J.Y., Harris, N.D., Haché, C.A., Li, D.H., and Crawford, B.D. (2009) The Zebrafish Embryo: A Powerful Model System for Investigating Matrix Remodeling. Zebrafish. 6(4):347-354

Coyle, R.C., Latimer, A., and Jessen, J.R. (2008) Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: Evidence for an interaction with non-canonical Wnt signaling. Experimental cell research. 314(10):2150-2162

Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63

Lien, C.L., Schebesta, M., Makino, S., Weber, G.J., and Keating, M.T. (2006) Gene Expression Analysis of Zebrafish Heart Regeneration. PLoS Biology. 4(8):e260

Bai, S., Thummel, R., Godwin, A.R., Nagase, H., Itoh, Y., Li, L., Evans, R., McDermott, J., Seiki, M., and Sarras, M.P. Jr. (2005) Matrix metalloproteinase expression and function during fin regeneration in zebrafish: Analysis of MT1-MMP, MMP2 and TIMP2. Matrix biology : journal of the International Society for Matrix Biology. 24(4):247-260

Zhang, J., Bai, S., Zhang, X., Nagase, H., and Sarras, M.P. (2003) The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos. Matrix biology : journal of the International Society for Matrix Biology. 22(3):279-293

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (19):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2022) Nomenclature Data Curation (2022). Nomenclature Committee Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M.S., Lewis, S.E., Thomas, P.D. (2010) Annotation inferences using phylogenetic trees. Automated Data Submission. 12:449-62

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.