PUBLICATION

The regenerative response of cardiac interstitial cells

Authors
Rolland, L., Harrington, A., Faucherre, A., Abaroa, J.M., Gangatharan, G., Gamba, L., Severac, D., Pratlong, M., Moore-Morris, T., Jopling, C.
ID
ZDB-PUB-221023-5
Date
2022
Source
Journal of molecular cell biology   14(10): (Journal)
Registered Authors
Faucherre, Adele, Jopling, Chris
Keywords
none
MeSH Terms
  • Humans
  • Zebrafish
  • Cell Proliferation
  • Animals, Genetically Modified
  • Animals
  • Myocardial Infarction*
  • Myocytes, Cardiac*
(all 7)
PubMed
36271843 Full text @ J. Mol. Cell Biol.
Abstract
Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial infarction. Currently, it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac regeneration. To understand how interstitial cells behave during this process, we performed single-cell RNA sequencing (scRNA-seq) of regenerating zebrafish hearts. Using a combination of immunohistochemistry, chemical inhibition, and novel transgenic animals, we were able to investigate the role of cell type-specific mechanisms during cardiac regeneration. This approach allowed us to identify a number of important regenerative processes within the interstitial cell populations. Here, we provide detailed insight into how interstitial cells behave during cardiac regeneration, which will serve to increase our understanding of how this process could eventually be induced in humans.
Genes / Markers
Figures
Figure Gallery (8 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
cn11TgTransgenic Insertion
    mmr7TgTransgenic Insertion
      mmr8TgTransgenic Insertion
        pd37TgTransgenic Insertion
          sd2TgTransgenic Insertion
            twu34TgTransgenic Insertion
              ump2TgTransgenic Insertion
                vu295aTgTransgenic Insertion
                  y1TgTransgenic Insertion
                    1 - 9 of 9
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                    Human Disease / Model
                    No data available
                    Sequence Targeting Reagents
                    No data available
                    Fish
                    No data available
                    Antibodies
                    Name Type Antigen Genes Isotypes Host Organism
                    Ab1-actmonoclonal
                      		IgMMouse
                      Ab1-rspo1polyclonal
                        		IgGRabbit
                        Ab2-tal1polyclonal
                          		IgGRabbit
                          Ab4-mef2monoclonal
                            		IgGRabbit
                            Ab5-mmp14polyclonal
                              		Goat
                              1 - 5 of 5
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                              Orthology
                              No data available
                              Engineered Foreign Genes
                              Marker Marker Type Name
                              CreEFGCre
                              DsRedEFGDsRed
                              DsRed2EFGDsRed2
                              EGFPEFGEGFP
                              mCherryEFGmCherry
                              NTREFGNTR
                              RFPEFGRFP
                              1 - 7 of 7
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                              Mapping
                              No data available
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                              Citation
                              Rolland, L., Harrington, A., Faucherre, A., Abaroa, J.M., Gangatharan, G., Gamba, L., Severac, D., Pratlong, M., Moore-Morris, T., Jopling, C. (2022) The regenerative response of cardiac interstitial cells. Journal of molecular cell biology. 14(10):.