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ZFIN ID:
ZDB-GENE-021223-3
CITATIONS
(40 total)
Gene Name:
melanocortin 5a receptor
Gene Symbol:
mc5ra
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
Godino-Gimeno, A., Rocha, A., Chivite, M., Saera-Vila, A., Rotllant, J., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Agouti-induced anxiety-like behaviour is mediated by central serotonergic pathways in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(32):
Haitina, T., Klovins, J., Takahashi, A., Löwgren, M., Ringholm, A., Enberg, J., Kawauchi, H., Larson, E.T., Fredriksson, R., and Schiöth, H.B. (2007) Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. BMC Evolutionary Biology. 7:101
Josep Agulleiro, M., Cortés, R., Fernández-Durán, B., Navarro, S., Guillot, R., Meimaridou, E., Clark, A.J., and Cerdá-Reverter, J.M. (2013) Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2. Molecular endocrinology (Baltimore, Md.). 27(11):1934-1945
Kumar, A., Bhandari, A., Sinha, R., Goyal, P., and Grapputo, A. (2011) Spliceosomal Intron Insertions in Genome Compacted Ray-Finned Fishes as Evident from Phylogeny of MC Receptors, Also Supported by a Few Other GPCRs. PLoS One. 6(8):e22046
Liao, S., Dong, J., Xu, W., Xi, B., Tao, Y., Liu, B., Xie, J. (2018) Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor. Fish physiology and biochemistry. 45(1):311-321
Logan, D.W., Bryson-Richardson, R.J., Pagan, K.E., Taylor, M.S., Currie, P.D., and Jackson, I.J. (2003) The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics. 81(2):184-191
Logan, D.W., Bryson-Richardson, R.J., Taylor, M.S., Currie, P., and Jackson, I.J. (2003) Sequence characterization of teleost fish melanocortin receptors. Annals of the New York Academy of Sciences. 994:319-330
Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):
Reinick, C.L., Liang, L., Angleson, J.K., and Dores, R.M. (2012) Functional expression of Squalus acanthias melanocortin-5 receptor in CHO cells: Ligand selectivity and interaction with MRAP. European Journal of Pharmacology. 680(1-3):1-7
Renquist, B.J., Zhang, C., Williams, S.Y., and Cone, R.D. (2013) Development of an Assay for High-Throughput Energy Expenditure Monitoring in the Zebrafish. Zebrafish. 10(3):343-52
Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J.H., Larhammar, D., and Schiöth, H.B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. Journal of neurochemistry. 82(1):6-18
Selz, Y., Braasch, I., Hoffmann, C., Schmidt, C., Schultheis, C., Schartl, M., and Volff, J.N. (2007) Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor. Gene. 401(1-2):114-122
Shainer, I., Michel, M., Marquart, G.D., Bhandiwad, A.A., Zmora, N., Ben-Moshe Livne, Z., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., Hollander-Cohen, L., Cone, R.D., Burgess, H.A., Gothilf, Y. (2019) Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. Current biology : CB. 29(12):2009-2019.e7
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
Sánchez, E., Rubio, V.C., Thompson, D.A., Metz, J., Flik, G., Millhauser, G.L., and Cerda-Reverter, J.M. (2009) Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1293-R1306
Wang, H., Semenova, S., Kuusela, S., Panula, P., Lehtonen, S. (2015) Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11):4435-48
Zhang, C., Forlano, P.M., and Cone, R.D. (2012) AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metabolism. 15(2):256-264
Zhang, C., Song, Y., Thompson, D.A., Madonna, M.A., Millhauser, G.L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., Cone, R.D. (2010) Pineal-specific agouti protein regulates teleost background adaptation. Proceedings of the National Academy of Sciences of the United States of America. 107(47):20164-71
Zhu, M., Wang, M., Chen, Y., Zhang, C. (2019) Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Journal of molecular endocrinology.
Godino-Gimeno, A., Rocha, A., Chivite, M., Saera-Vila, A., Rotllant, J., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Agouti-induced anxiety-like behaviour is mediated by central serotonergic pathways in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(32):
Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):
Shainer, I., Michel, M., Marquart, G.D., Bhandiwad, A.A., Zmora, N., Ben-Moshe Livne, Z., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., Hollander-Cohen, L., Cone, R.D., Burgess, H.A., Gothilf, Y. (2019) Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. Current biology : CB. 29(12):2009-2019.e7
Zhu, M., Wang, M., Chen, Y., Zhang, C. (2019) Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Journal of molecular endocrinology.
Liao, S., Dong, J., Xu, W., Xi, B., Tao, Y., Liu, B., Xie, J. (2018) Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor. Fish physiology and biochemistry. 45(1):311-321
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
Wang, H., Semenova, S., Kuusela, S., Panula, P., Lehtonen, S. (2015) Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11):4435-48
Josep Agulleiro, M., Cortés, R., Fernández-Durán, B., Navarro, S., Guillot, R., Meimaridou, E., Clark, A.J., and Cerdá-Reverter, J.M. (2013) Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2. Molecular endocrinology (Baltimore, Md.). 27(11):1934-1945
Renquist, B.J., Zhang, C., Williams, S.Y., and Cone, R.D. (2013) Development of an Assay for High-Throughput Energy Expenditure Monitoring in the Zebrafish. Zebrafish. 10(3):343-52
Reinick, C.L., Liang, L., Angleson, J.K., and Dores, R.M. (2012) Functional expression of Squalus acanthias melanocortin-5 receptor in CHO cells: Ligand selectivity and interaction with MRAP. European Journal of Pharmacology. 680(1-3):1-7
Zhang, C., Forlano, P.M., and Cone, R.D. (2012) AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metabolism. 15(2):256-264
Kumar, A., Bhandari, A., Sinha, R., Goyal, P., and Grapputo, A. (2011) Spliceosomal Intron Insertions in Genome Compacted Ray-Finned Fishes as Evident from Phylogeny of MC Receptors, Also Supported by a Few Other GPCRs. PLoS One. 6(8):e22046
Zhang, C., Song, Y., Thompson, D.A., Madonna, M.A., Millhauser, G.L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., Cone, R.D. (2010) Pineal-specific agouti protein regulates teleost background adaptation. Proceedings of the National Academy of Sciences of the United States of America. 107(47):20164-71
Sánchez, E., Rubio, V.C., Thompson, D.A., Metz, J., Flik, G., Millhauser, G.L., and Cerda-Reverter, J.M. (2009) Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1293-R1306
Haitina, T., Klovins, J., Takahashi, A., Löwgren, M., Ringholm, A., Enberg, J., Kawauchi, H., Larson, E.T., Fredriksson, R., and Schiöth, H.B. (2007) Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. BMC Evolutionary Biology. 7:101
Selz, Y., Braasch, I., Hoffmann, C., Schmidt, C., Schultheis, C., Schartl, M., and Volff, J.N. (2007) Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor. Gene. 401(1-2):114-122
Logan, D.W., Bryson-Richardson, R.J., Pagan, K.E., Taylor, M.S., Currie, P.D., and Jackson, I.J. (2003) The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics. 81(2):184-191
Logan, D.W., Bryson-Richardson, R.J., Taylor, M.S., Currie, P., and Jackson, I.J. (2003) Sequence characterization of teleost fish melanocortin receptors. Annals of the New York Academy of Sciences. 994:319-330
Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J.H., Larhammar, D., and Schiöth, H.B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. Journal of neurochemistry. 82(1):6-18
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
Additional Citations (20):
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.
ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.
ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.
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