ZFIN

ZFIN ID: ZDB-GENE-010126-2

ZFIN ID: ZDB-GENE-010126-2

CITATIONS (67 total)

Gene Name:	neurotrophic tyrosine kinase, receptor, type 2b
Gene Symbol:	ntrk2b

Leggieri, A., García-González, J., Hosseinian, S., Ashdown, P., Anagianni, S., Wang, X., Havelange, W., Fernàndez-Castillo, N., Cormand, B., Brennan, C.H. (2025) rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood. Translational psychiatry. :

Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m⁶A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014

Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):

Nishida, T., Horita, C., Imagawa, M., Hibarino, M., Tateno, S., Kubo, Y., Kawabe, M., Morishita, N., Endo, S., Shiozaki, K. (2023) Glucosyl hesperidin exhibits more potent anxiolytic activity than hesperidin accompanied by the attenuation of noradrenaline induction in a zebrafish model. Frontiers in pharmacology. 14:12132521213252

Cacialli, P., Lucini, C. (2022) Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney. Veterinary sciences. 9(6)

Maffioli, E., Angiulli, E., Nonnis, S., Grassi Scalvini, F., Negri, A., Tedeschi, G., Arisi, I., Frabetti, F., D'Aniello, S., Alleva, E., Cioni, C., Toni, M. (2022) Brain Proteome and Behavioural Analysis in Wild Type, BDNF^+/- and BDNF^-/- Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. International Journal of Molecular Sciences. 23(10)

Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705

Chen, Z., Zhijie, C., Yuting, Z., Chan, L., Shilin, X., Qichun, Z., Jinying, O., Jing, L., Chaohua, L., Zhixian, M. (2021) The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Frontiers in pharmacology. 12:526923

Desvignes, T., Sydes, J., Montfort, J., Bobe, J., Postlethwait, J.H. (2021) Evolution after whole genome duplication: teleost microRNAs. Molecular Biology and Evolution. 38(8):3308-3331

Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8

Jung, J., Kim, E., Rhee, M. (2021) Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos. Molecules and cells. 44(4):233-244

Lüffe, T.M., D'Orazio, A., Bauer, M., Gioga, Z., Schoeffler, V., Lesch, K.P., Romanos, M., Drepper, C., Lillesaar, C. (2021) Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Translational psychiatry. 11:529

Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):

Barbereau, C., Yehya, A., Silhol, M., Cubedo, N., Verdier, J.M., Maurice, T., Rossel, M. (2020) Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological research. 158:104865

Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727

Chen, Z., Zhijie, C., Yuting, Z., Shilin, X., Qichun, Z., Jinying, O., Chaohua, L., Jing, L., Zhixian, M. (2020) Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Frontiers in microbiology. 11:946

Germanà, A., Guerrera, M.C., Laurà, R., Levanti, M., Aragona, M., Mhalhel, K., Germanà, G., Montalbano, G., Abbate, F. (2020) Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear. International Journal of Molecular Sciences. 21(16):

Hahn, K., Manuel, P., Bouldin, C. (2020) Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish. PeerJ. 8:e10479

Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75

Kedra, M., Banasiak, K., Kisielewska, K., Wolinska-Niziol, L., Jaworski, J., Zmorzynska, J. (2020) TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex. Proceedings of the National Academy of Sciences of the United States of America. 117(4):2170-2179

Yang, L., Wang, J., Wang, D., Hu, G., Liu, Z., Yan, D., Serikuly, N., Alpyshov, E., Demin, K.A., Strekalova, T., de Abreu, M.S., Song, C., Kalueff, A. (2020) Delayed behavioral and genomic responses to acute combined stress in zebrafish, potentially relevant to PTSD and other stress-related disorders: focus on neuroglia, neuroinflammation, apoptosis and epigenetic modulation. Behavioural brain research. 389:112644

Sahu, M.P., Pazos-Boubeta, Y., Pajanoja, C., Rozov, S., Panula, P., Castrén, E. (2019) Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish. Scientific Reports. 9:2036

Wang, J., Li, Y., Lai, K., Zhong, Q., Demin, K.A., Kalueff, A.V., Song, C. (2019) High-glucose/high-cholesterol diet in zebrafish evokes diabetic and affective pathogenesis: The role of peripheral and central inflammation, microglia and apoptosis. Progress in neuro-psychopharmacology & biological psychiatry. 96:109752

Jin, M., Sheng, W., Han, L., He, Q., Ji, X., Liu, K. (2018) Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish & shellfish immunology. 83:26-36

Nittoli, V., Sepe, R.M., Coppola, U., D'Agostino, Y., De Felice, E., Palladino, A., Vassalli, Q.A., Locascio, A., Ristoratore, F., Spagnuolo, A., D'Aniello, S., Sordino, P. (2018) A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish. The Journal of comparative neurology. 526(6):1057-1072

den Broeder, M.J., Moester, M.J.B., Kamstra, J.H., Cenijn, P.H., Davidoiu, V., Kamminga, L.M., Ariese, F., de Boer, J.F., Legler, J. (2017) Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy. International Journal of Molecular Sciences. 18(4)

Song, C., Liu, B.P., Zhang, Y.P., Peng, Z., Wang, J., Collier, A.D., Echevarria, D.J., Savelieva, K.V., Lawrence, R.F., Rex, C.S., Meshalkina, D.A., Kalueff, A.V. (2017) Modeling consequences of prolonged strong unpredictable stress in zebrafish: Complex effects on behavior and physiology. Progress in neuro-psychopharmacology & biological psychiatry. 81:384-394

Montalbano, G., Mania, M., Guerrera, M.C., Abbate, F., Laurà, R., Navarra, M., Vega, J.A., Ciriaco, E., Germanà, A. (2016) Morphological differences in adipose tissue and changes in BDNF/Trkb expression in brain and gut of a diet induced obese zebrafish model. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 204:36-44

Gasanov, E.V., Rafieva, L.M., Korzh, V.P. (2015) BDNF-TrkB Axis Regulates Migration of the Lateral Line Primordium and Modulates the Maintenance of Mechanoreceptor Progenitors. PLoS One. 10:e0119711

Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23

Abbate, F., Guerrera, M.C., Montalbano, G., Levanti, M.B., Germanà, G.P., Navarra, M., Laurà, R., Vega, J.A., Ciriaco, E., and Germanà, A. (2014) Expression and anatomical distribution of TrkB in the encephalon of the adult zebrafish (Danio rerio). Neuroscience letters. 563:66-69

Sánchez-Ramos, C., Bonnin-Arias, C., Guerrera, M.C., Calavia, M.G., Chamorro, E., Montalbano, G., López-Velasco, S., López-Muñiz, A., Germanà, A., and Vega, J.A. (2013) Light regulates the expression of the BDNF/TrkB system in the adult Zebrafish retina. Microscopy research and technique. 76(1):42-49

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Mo, W., and Nicolson, T. (2011) Both pre- and postsynaptic activity of nsf prevents degeneration of hair-cell synapses. PLoS One. 6(11):e27146

Germanà, A., Laurà, R., Montalbano, G., Guerrera, M.C., Amato, V., Zichichi, R., Campo, S., Ciriaco, E., and Vega, J.A. (2010) Expression of Brain-Derived Neurotrophic Factor and TrkB in the Lateral Line System of Zebrafish During Development. Cellular and molecular neurobiology. 30(5):787-793

Germanà, A., Sánchez-Ramos, C., Guerrera, M.C., Calavia, M.G., Navarro, M., Zichichi, R., García-Suárez, O., Pérez-Piñera, P., and Vega, J.A. (2010) Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development. Journal of anatomy. 217(3):214-222

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Phillips, R.B., Amores, A., Morasch, M.R., Wilson, C., and Postlethwait, J.H. (2006) Assignment of zebrafish genetic linkage groups to chromosomes. Cytogenetic and genome research. 114(2):155-162

Tallafuss, A., Hale, L.A., Yan, Y.L., Dudley, L., Eisen, J.S., and Postlethwait, J.H. (2006) Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Gene expression patterns : GEP. 6(5):556-565

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Martin, S.C., Marazzi, G., Sandell, J.H., and Heinrich, G. (1995) Five Trk receptors in the zebrafish. Developmental Biology. 169:745-758

Additional Citations (26):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission. ZFIN Direct Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

Thisse, B., Wright, G.J., Thisse, C. (2008) Embryonic and Larval Expression Patterns from a Large Scale Screening for Novel Low Affinity Extracellular Protein Interactions. ZFIN Direct Data Submission.

ZF-MODELS Consortium (2007) ZF-MODELS Consortium and Zebrafish Mutation Resource targeted knock-out mutants. ZFIN Direct Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.