ZFIN ID: ZDB-PUB-180113-8
A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish
Nittoli, V., Sepe, R.M., Coppola, U., D'Agostino, Y., De Felice, E., Palladino, A., Vassalli, Q.A., Locascio, A., Ristoratore, F., Spagnuolo, A., D'Aniello, S., Sordino, P.
Date: 2018
Source: The Journal of comparative neurology   526(6): 1057-1072 (Journal)
Registered Authors: D'Aniello, Salvatore, Sordino, Paolo
Keywords: RRID:SCR_008439, development, neurotrophin tyrosine kinase receptors, neurotrophins, phylogeny, zebrafish
MeSH Terms:
  • Animals
  • Embryo, Nonmammalian
  • Gene Expression Regulation, Developmental/physiology*
  • Humans
  • Nerve Growth Factors/genetics
  • Nerve Growth Factors/metabolism*
  • Phylogeny
  • RNA, Messenger/metabolism
  • Receptor Protein-Tyrosine Kinases/genetics
  • Receptor Protein-Tyrosine Kinases/metabolism*
  • Receptors, Nerve Growth Factor/genetics
  • Receptors, Nerve Growth Factor/metabolism*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
PubMed: 29322524 Full text @ J. Comp. Neurol.
Neurotrophins (NTF) are a family of secreted nerve growth factors with affinity for tyrosine kinase (Ntrk) and p75 receptors. To fully understand the variety of developmental roles played by NTFs, it is critical to know when and where genes encoding individual ligands and receptors are transcribed. Identification of ntf and ntrk transcripts in zebrafish development remains to be fully characterized for further uncovering the potential function(s) of the NTF signal transduction pathway. Here, we conducted a systematic analysis of the expression profiles of four ntf and five ntrk genes during zebrafish development using whole-mount in situ hybridization. Our study unveils new expression domains in the developing embryo, confirms those previously known, and shows that ntf and ntrk genes have different degrees of cell- and tissue-type specificity. The unique and overlapping expression patterns here depicted indicate the coordination of the redundant and divergent functions of NTFs and represent valuable tools for deciphering the molecular pathways involved in the specification and function of embryonic cell types. This article is protected by copyright. All rights reserved.