Publication	Data		Fish	Anatomy
Shangguan et al., 2024	Fig. 1.		AB + CRISPR14-kmt2d + CRISPR15-kmt2d + CRISPR16-kmt2d	ceratohyal cartilage dysplastic, abnormal ethmoid cartilage dysplastic, abnormal extension decreased size, abnormal eye decreased size, abnormal Meckel's cartilage decreased distance ceratohyal cartilage, abnormal Meckel's cartilage dysplastic, abnormal pericardium edematous, abnormal post-vent region curved, abnormal ventral mandibular arch morphology, abnormal whole organism kmt2d expression decreased amount, abnormal whole organism Ab65-h3 labeling decreased amount, abnormal whole organism decreased length, abnormal
	Fig. 5.		AB + CRISPR14-kmt2d + CRISPR15-kmt2d + CRISPR16-kmt2d	ceratohyal cartilage dysplastic, abnormal Meckel's cartilage decreased distance ceratohyal cartilage, abnormal Meckel's cartilage dysplastic, abnormal whole organism Ab24-ctnnb labeling increased amount, abnormal whole organism ab5-akt labeling increased amount, abnormal whole organism decreased length, abnormal
Liang et al., 2020	Fig. 2		f1Tg + CRISPR13-kmt2d	determination of heart left/right asymmetry process quality, abnormal heart looping process quality, abnormal heart position, abnormal
	Fig. 3		AB + CRISPR13-kmt2d	determination of liver left/right asymmetry disrupted, abnormal liver mislocalised, abnormal
	Fig. 4		AB + CRISPR13-kmt2d	determination of left/right symmetry process quality, abnormal
Serrano et al., 2019	Fig 1		kmt2dzy60/zy60 (AB) ,   kmt2dzy59/zy59 (AB) ,   kmt2dzy58/zy58 (AB)	head decreased size, abnormal pericardium edematous, abnormal whole organism anterior-posterior axis decreased length, abnormal
	Fig 2		kmt2dzy59/zy59 (AB)	basihyal cartilage absent, abnormal cranial cartilage lacks parts or has fewer parts of type palatoquadrate cartilage, abnormal ethmoid cartilage decreased length, abnormal ethmoid cartilage morphology, abnormal head decreased size, abnormal Meckel's cartilage absent, abnormal pharyngeal arch cartilage lacks parts or has fewer parts of type ceratohyal cartilage, abnormal pharyngeal arch cartilage lacks parts or has fewer parts of type hyosymplectic cartilage, abnormal ventral hyoid arch lacks parts or has fewer parts of type ceratobranchial cartilage, abnormal ventral hyoid arch malformed, abnormal
	Fig 3		kmt2dzy59/zy59; la116Tg	cardiac ventricle hypoplastic, abnormal cardiac ventricle lumen obstructed, abnormal heart contraction decreased rate, abnormal ventricular endocardium cell division decreased occurrence, abnormal ventricular endocardium hypoplastic, abnormal ventricular endocardium morphology, abnormal ventricular endocardium separated from ventricular myocardium, abnormal
	Fig 4		kmt2dzy59/zy59; la116Tg	anterior cerebral vein misrouted, abnormal aortic arch 1 immature, abnormal central artery misrouted, abnormal cranial blood vessel lumen decreased diameter, abnormal cranial vasculature malformed, abnormal dorsal ciliary vein increased diameter, abnormal hypobranchial artery incomplete structure, abnormal inner optic circle increased diameter, abnormal nasal ciliary artery increased diameter, abnormal oral region vasculature decreased size, abnormal pharyngeal arch 3-7 lacks parts or has fewer parts of type aortic arch, abnormal vascular endothelium endothelial cell proliferation decreased occurrence, abnormal ventral aorta misrouted, abnormal
	Fig 5		kmt2dzy59/zy59; la116Tg	aortic arch 1 has extra parts of type angiogenic sprout, abnormal aortic arch angiogenesis delayed, abnormal aortic arch lumen decreased diameter, abnormal lateral dorsal aorta ventral region lacks parts or has fewer parts of type aortic arch, abnormal opercular artery decreased size, abnormal opercular artery has extra parts of type angiogenic sprout, abnormal
	Fig 6		kmt2dzy59/zy59 (AB) ,   um14Tg + CRISPR12-kmt2d ,   kmt2dzy59/zy59; la116Tg	atrium notch1b expression spatial pattern, abnormal cardiac ventricle notch1b expression increased distribution, abnormal heart rbpja expression increased amount, abnormal heart morphology, abnormal heart nucleus rbpja expression increased amount, abnormal whole organism rbpja expression increased amount, abnormal
	Fig 7		kmt2dzy59/zy59; la116Tg	aortic arch cell population proliferation decreased occurrence, abnormal aortic arch morphology, abnormal cranial vasculature malformed, abnormal endocardium cell population proliferation decreased occurrence, abnormal head muscle ab-mf20 labeling spatial pattern, abnormal pericardium edematous, abnormal sternohyoid deformed, abnormal
	Fig 8		kmt2dzy59/zy59; la116Tg	endocardium rbpja expression increased distribution, abnormal
	Fig 9		kmt2dzy59/zy59; la116Tg	aortic arch morphology, abnormal
Tsai et al., 2018	Fig. 1		EKW + MO5-kmt2d	convergent extension involved in gastrulation disrupted, abnormal whole organism dead, abnormal
	Fig. 2		EKW + MO5-kmt2d	convergent extension involved in gastrulation disrupted, abnormal mandibular arch skeleton morphology, abnormal Meckel's cartilage decreased distance ceratohyal cartilage, abnormal
	Fig. 4		EKW + MO5-kmt2d	head Ab5-map2k1/2 labeling increased amount, abnormal MAP kinase kinase activity increased rate, abnormal
	Fig. 5		EKW + MO5-kmt2d	brain cell population proliferation decreased occurrence, abnormal
	Fig. 6		kmt2drdu1001/rdu1001	brain cell population proliferation decreased occurrence, abnormal convergent extension involved in gastrulation disrupted, abnormal mandibular arch skeleton morphology, abnormal Meckel's cartilage decreased distance ceratohyal cartilage, abnormal
	Fig. S5		EKW + MO5-kmt2d	convergent extension involved in gastrulation disrupted, abnormal
	Fig. S7		EKW + CRISPR10-kmt2d	convergent extension involved in gastrulation disrupted, abnormal mandibular arch skeleton morphology, abnormal Meckel's cartilage decreased distance ceratohyal cartilage, abnormal
Bögershausen et al., 2015	Fig. 10		WT + MO5-kmt2d	MAP kinase kinase activity process quality, abnormal
	Fig. 5		WT + MO6-kmt2d ,   WT + MO5-kmt2d	convergent extension disrupted, abnormal notochord increased width, abnormal whole organism anterior-posterior axis shortened, abnormal
	Fig. 6		WT + MO5-kmt2d	ceratohyal cartilage increased width, abnormal ceratohyal cartilage kinked, abnormal ceratohyal cartilage shortened, abnormal Meckel's cartilage decreased distance ceratohyal cartilage, abnormal
	Fig. S4		WT + MO5-kmt2d	ceratohyal cartilage chondrocyte disorganized, abnormal chondrocyte filamentous actin position, abnormal chondrocyte myosin II filament position, abnormal
Van Laarhoven et al., 2015	Fig. 2		AB/TL + MO2-kmt2d + MO3-kmt2d	embryonic viscerocranium morphogenesis decreased process quality, abnormal ethmoid cartilage truncated, abnormal head lacks all parts of type ceratohyal cartilage, abnormal head lacks all parts of type cleithrum, abnormal head lacks all parts of type Meckel's cartilage, abnormal head lacks all parts of type opercle, abnormal head lacks all parts of type pharyngeal arch 3-7, abnormal neurocranial trabecula truncated, abnormal
	Fig. 3		co10Tg + MO2-kmt2d + MO4-kmt2d	cardiac ventricle orientation atrium, abnormal heart development disrupted, abnormal heart looping process quality, abnormal
	Fig. 4		AB/TL + MO2-kmt2d + MO3-kmt2d	brain decreased size, abnormal brain development process quality, abnormal forebrain nucleus elongated, abnormal hypothalamus decreased thickness, abnormal midbrain nucleus elongated, abnormal optic tectum decreased thickness, abnormal tegmentum decreased thickness, abnormal
	Fig. 5		AB/TL + MO2-kmt2d + MO3-kmt2d	forebrain neuron differentiation decreased process quality, abnormal midbrain neuron differentiation decreased process quality, abnormal
	Fig. S3		AB/TL + MO2-kmt2d + MO3-kmt2d	pericardium edematous, abnormal
	Fig. S4		AB/TL + MO2-kmt2d + MO3-kmt2d	hindbrain decreased size, abnormal medulla oblongata decreased thickness, abnormal