FIGURE
Fig. 2
- ID
- ZDB-FIG-180828-62
- Publication
- Tsai et al., 2018 - Small molecule inhibition of RAS/MAPK signaling ameliorates developmental pathologies of Kabuki Syndrome
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Fig. 2
Compounds 2 and 8 ameliorate CE and jaw defects caused by loss of kmt2d. (a) Compounds 2 and 8, but not 28 (negative control), rescue CE defects of kmt2d morphants. (b) Alcian blue staining of jaw. Depletion of kmt2d leads to a change in jaw layout, reducing the distance between Meckel’s (MK) cartilage and ceratohyal (CH) cartilage (red double arrow). Treatment with compound 2 or 8, but not 28, ameliorates this defect in kmt2d morphants. (c) Quantitative measurement of the distance between MK and CH cartilages (n > 25). *p < 0.05; **p < 0.01; ***p < 0.001. Error bars show SEM (standard error of the mean). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
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| Conditions: | |
| Knockdown Reagent: | |
| Observed In: | |
| Stage Range: | Prim-5 to Day 5 |
Phenotype Detail
Acknowledgments
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